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Inhibitors
| Cat.No. | Name | Information |
|---|---|---|
| M8692 | ML385 | ML385 was a specific NRF2 inhibitor with an IC50 of 1.9 μM. ML385 inhibits Nrf2 transcription factor activity by binding to Neh1, an NC-Bzip domain that allows Nrf2 to heterodimerize with small Maf proteins, blocking Nrf2 transcriptional activity. |
| M20776 | cis-Resveratrol | cis-Resveratrol (cis-RESV, cRes, (Z)-Resveratrol) is the Cis isomer of Resveratrol. Resveratrol is a natural phenolic compound with anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol is an inhibitor of pregnane X receptor (PXR) and an activator of Nrf2 and SIRT1 and may induce apoptosis. |
| M14596 | Nrf2-IN-1 | Nrf2-IN-1 is an inhibitor of nuclear factor-erythroid 2-related factor 2 (Nrf2). Nrf2-IN-1 is developed for the research of acute myeloid leukemia (AML). |
| M14595 | NK-252 | NK-252 is a potential Nrf2 activator, which exhibits a great Nrf2-activating potential. |
| M14594 | KI696 | KI696 is a high affinity probe that disrupts the Keap1/NRF2 interaction. KI696 is a potent and selective inhibitor of the KEAP1/NRF2 interaction. |
| M14593 | Keap1-Nrf2-IN-1 | Keap1-Nrf2-IN-1 is a Keap1 (Kelch-like ECH-associated protein 1)-Nrf2 (nuclear factor erythroid 2-related factor 2) protein-protein interaction inhibitor, and with an IC50 of 43 nM for Keap1 protein. |
| M14592 | CDDO-EA | CDDO-EA is an NF-E2 related factor 2/antioxidant response element (Nrf2/ARE) activator. |
| M14591 | (+)-DHMEQ | (+)-DHMEQ is an activator of antioxidant transcription factor Nrf2. (+)-DHMEQ is the enantiomer of (-)-DHMEQ. (-)-DHMEQ inhibits NF-kB than its enantiomer (+)-DHMEQ. |
| M10081 | Omaveloxolone | Omaveloxolone (RTA 408) is an antioxidant inflammatory modulator (AIM) that activates Nrf2 and inhibits nitric oxide (NO).Omaveloxolone inhibits osteoclastogenesis by inhibiting the STING-dependent NF-κb signaling pathway. |
| M9604 | Kinsenoside | Kinsenoside is a main active component isolated from plants of the genus Anoectochilus, and exhibits many biological activities and pharmacological effects. |
| M9225 | 4-Octyl Itaconate | 4-Octyl Itaconate is a cell-permeable anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1. |
| M9140 | Hinokitiol | Hinokitiol (β-thujaplicin) is a component of essential oils isolated from Chymacyparis obtusa, reduces Nrf2 expression, and decreases DNMT1 and UHRF1 mRNA and protein expression, with anti-infective, anti-oxidative, and anti-tumor activities. |
| M8710 | Brusatol | Brusatol (Brutasol) is a plant-derived natural quassinoid that exhibits broad cytotoxicity in cancer cultures (IC50 <1 μM against 457 cancer cell lines) by inhibiting de novo synthesis of cellular proteins (Effective conc. |
| M8692 | ML385 | ML385 was a specific NRF2 inhibitor with an IC50 of 1.9 μM. ML385 inhibits Nrf2 transcription factor activity by binding to Neh1, an NC-Bzip domain that allows Nrf2 to heterodimerize with small Maf proteins, blocking Nrf2 transcriptional activity. |
| M8404 | Danshensu | Danshensu is an active component of Salvia miltiorrhiza (Danshen) that suppresses the formation of reactive oxygen species, inhibits platelet adhesion and aggregation, and protects myocardium against ischemia. |
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