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Nrf2 Nuclear factor (erythroid-derived 2)-like 2

Inhibitors

Cat.No.  Name Information
M8692 ML385 ML385 was a specific NRF2 inhibitor with an IC50 of 1.9 μM. ML385 inhibits Nrf2 transcription factor activity by binding to Neh1, an NC-Bzip domain that allows Nrf2 to heterodimerize with small Maf proteins, blocking Nrf2 transcriptional activity.
M20776 cis-Resveratrol cis-Resveratrol (cis-RESV, cRes, (Z)-Resveratrol) is the Cis isomer of Resveratrol. Resveratrol is a natural phenolic compound with anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol is an inhibitor of pregnane X receptor (PXR) and an activator of Nrf2 and SIRT1 and may induce apoptosis.
M14596 Nrf2-IN-1 Nrf2-IN-1 is an inhibitor of nuclear factor-erythroid 2-related factor 2 (Nrf2). Nrf2-IN-1 is developed for the research of acute myeloid leukemia (AML).
M14595 NK-252 NK-252 is a potential Nrf2 activator, which exhibits a great Nrf2-activating potential.
M14594 KI696 KI696 is a high affinity probe that disrupts the Keap1/NRF2 interaction. KI696 is a potent and selective inhibitor of the KEAP1/NRF2 interaction.
M14593 Keap1-Nrf2-IN-1 Keap1-Nrf2-IN-1 is a Keap1 (Kelch-like ECH-associated protein 1)-Nrf2 (nuclear factor erythroid 2-related factor 2) protein-protein interaction inhibitor, and with an IC50 of 43 nM for Keap1 protein.
M14592 CDDO-EA CDDO-EA is an NF-E2 related factor 2/antioxidant response element (Nrf2/ARE) activator.
M14591 (+)-DHMEQ (+)-DHMEQ is an activator of antioxidant transcription factor Nrf2. (+)-DHMEQ is the enantiomer of (-)-DHMEQ. (-)-DHMEQ inhibits NF-kB than its enantiomer (+)-DHMEQ.
M10081 Omaveloxolone Omaveloxolone (RTA 408) is an antioxidant inflammatory modulator (AIM) that activates Nrf2 and inhibits nitric oxide (NO).Omaveloxolone inhibits osteoclastogenesis by inhibiting the STING-dependent NF-κb signaling pathway.
M9604 Kinsenoside Kinsenoside is a main active component isolated from plants of the genus Anoectochilus, and exhibits many biological activities and pharmacological effects.
M9225 4-Octyl Itaconate 4-Octyl Itaconate is a cell-permeable anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.
M9140 Hinokitiol Hinokitiol (β-thujaplicin) is a component of essential oils isolated from Chymacyparis obtusa, reduces Nrf2 expression, and decreases DNMT1 and UHRF1 mRNA and protein expression, with anti-infective, anti-oxidative, and anti-tumor activities.
M8710 Brusatol Brusatol (Brutasol) is a plant-derived natural quassinoid that exhibits broad cytotoxicity in cancer cultures (IC50 <1 μM against 457 cancer cell lines) by inhibiting de novo synthesis of cellular proteins (Effective conc.
M8692 ML385 ML385 was a specific NRF2 inhibitor with an IC50 of 1.9 μM. ML385 inhibits Nrf2 transcription factor activity by binding to Neh1, an NC-Bzip domain that allows Nrf2 to heterodimerize with small Maf proteins, blocking Nrf2 transcriptional activity.
M8404 Danshensu Danshensu is an active component of Salvia miltiorrhiza (Danshen) that suppresses the formation of reactive oxygen species, inhibits platelet adhesion and aggregation, and protects myocardium against ischemia.



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