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Keap1-Nrf2 Nuclear factor (erythroid-derived 2)-like 2


Cat.No.  Name Information
M10081 Omaveloxolone Omaveloxolone (RTA 408) is a first-in-class antioxidant inflammatory modulator (AIM) that activates Nrf2 and inhibits nitric oxide (NO). Omaveloxolone inhibits osteoclastogenesis by inhibiting the STING-dependent NF-κb signaling pathway.
M8692 ML385 ML385 was a specific nuclear factor erythroid 2-related factor 2 (NRF2) inhibitor with an IC50 of 1.9 μM. ML385 inhibits Nrf2 transcription factor activity by binding to Neh1.
M21431 Ezetimibe ketone Ezetimibe ketone (EZM-K) is a phase I metabolite of Ezetimibe. Ezetimibe is an NPC1L1 inhibitor, and Ezetimibe inhibits intestinal cholesterol absorption by preventing the absorption of cholesterol by the NPC1L1 protein. It is a potent Nrf2 activator.
M19174 Halleridone Halleridone is a natural product isolated from Halleria lucida (Scrophulariaceae), Teucrium decipiens, Phyla nodiflora and the stems of the plant Cornus walteri. Halleridone activated Nrf2-mediated HO-1 expression and inhibited Aβ1-42-overexpressed microglial BV-2 cell activation.
M14595 NK-252 NK-252 is a potential Nrf2 activator, which exhibits a great Nrf2-activating potential.
M14594 KI696 KI696 is a high affinity probe that disrupts the Keap1/NRF2 interaction. KI696 is a potent and selective inhibitor of the KEAP1/NRF2 interaction.
M14593 Keap1-Nrf2-IN-1 Keap1-Nrf2-IN-1 is a Keap1 (Kelch-like ECH-associated protein 1)-Nrf2 (nuclear factor erythroid 2-related factor 2) protein-protein interaction inhibitor, and with an IC50 of 43 nM for Keap1 protein.
M14592 CDDO-EA CDDO-EA is an NF-E2 related factor 2/antioxidant response element (Nrf2/ARE) activator.
M14591 (+)-DHMEQ (+)-DHMEQ is an activator of antioxidant transcription factor Nrf2. (+)-DHMEQ is the enantiomer of (-)-DHMEQ. (-)-DHMEQ inhibits NF-kB than its enantiomer (+)-DHMEQ.
M11261 CDDO-Im CDDO Im (RTA-403) is the activator of Nrf2 and PPAR with Ki of 232 nM and 344 nM for PPARα and PPARγ, respectively.
M9604 Kinsenoside Kinsenoside is a main active component isolated from plants of the genus Anoectochilus, and exhibits many biological activities and pharmacological effects.
M9225 4-Octyl Itaconate 4-Octyl Itaconate is a cell-permeable anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.
M9140 Hinokitiol Hinokitiol (β-thujaplicin) is a component of essential oils isolated from Chymacyparis obtusa, reduces Nrf2 expression, and decreases DNMT1 and UHRF1 mRNA and protein expression, with anti-infective, anti-oxidative, and anti-tumor activities.
M8891 AI-1 AI-1 is a negative regulator of Nrf2.
M8710 Brusatol Brusatol (Brutasol) is a plant-derived natural quassinoid that exhibits broad cytotoxicity in cancer cultures (IC50 <1 μM against 457 cancer cell lines) by inhibiting de novo synthesis of cellular proteins (Effective conc.
M8404 Danshensu Danshensu is an active component of Salvia miltiorrhiza (Danshen) that suppresses the formation of reactive oxygen species, inhibits platelet adhesion and aggregation, and protects myocardium against ischemia.
M6976 ML 334 ML 334 is a inhibitor of Keap1- Nrf2 interaction.
M4588 Astilbin Astilbin is a flavonoid that enhances NRF2 activation. Astilbin also inhibited TNF-α expression and NF-κB activation.
M4072 Ginsenoside-Rh3 Ginsenoside Rh3 is a bacterial metabolite of Ginsenoside Rg5. Ginsenoside Rh3 induces Nrf2 activation in human retinal cells.
M39209 Toralactone Toralactone, isolated from Cassia obtusifolia, mediates hepatoprotection via an Nrf2-dependent anti-oxidative mechanism.

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