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Keap1-Nrf2 Nuclear factor (erythroid-derived 2)-like 2

Inhibitor/Activator

Cat.No.  Name Information
M10081 Omaveloxolone Omaveloxolone (RTA 408) is a first-in-class antioxidant inflammatory modulator (AIM) that activates Nrf2 and inhibits nitric oxide (NO). Omaveloxolone inhibits osteoclastogenesis by inhibiting the STING-dependent NF-κb signaling pathway.
M8710 Brusatol Brusatol (NSC 172924) is a plant-derived natural quassinoid that exhibits broad cytotoxicity in cancer cultures (IC50 <1 μM against 457 cancer cell lines) by inhibiting de novo synthesis of cellular proteins (Effective conc. <50 nM in A549 cells), including NRF2.
M8692 ML385 ML385 was a specific nuclear factor erythroid 2-related factor 2 (NRF2) inhibitor with an IC50 of 1.9 μM. ML385 inhibits Nrf2 transcription factor activity by binding to Neh1.
M54409 TAT-14 TAT-14 is a 14-mer peptide that acts as Nrf2 activator with an anti-inflammatory effect.
M21431 Ezetimibe ketone Ezetimibe ketone (EZM-K) is a phase I metabolite of Ezetimibe. Ezetimibe is an NPC1L1 inhibitor, and Ezetimibe inhibits intestinal cholesterol absorption by preventing the absorption of cholesterol by the NPC1L1 protein. It is a potent Nrf2 activator.
M20956 Diroximel Fumarete Diroximel Fumarete, also known as ALKS-8700, is a prodrug of monomethyl fumarate in a controlled-release formulation that rapidly and efficiently converts to MMF in the body. Diroximel fumarate is a Nrf2 activator.
M19174 Halleridone Halleridone is a natural product isolated from Halleria lucida (Scrophulariaceae), Teucrium decipiens, Phyla nodiflora and the stems of the plant Cornus walteri. Halleridone activated Nrf2-mediated HO-1 expression and inhibited Aβ1-42-overexpressed microglial BV-2 cell activation.
M18229 Eriodictyol 7-O-glucoside Eriodictyol 7-O-glucoside
M17266 Gingerenone A Gingerenone A is a Nrf2-Gpx4 activator. Gingerenone A results a delayed G2/M in cancer cells, following oxidative stress and senescence responses.
M14596 Nrf2-IN-1 Nrf2-IN-1 is an inhibitor of nuclear factor-erythroid 2-related factor 2 (Nrf2). Nrf2-IN-1 is developed for the research of acute myeloid leukemia (AML).
M14595 NK-252 NK-252 is a potential Nrf2 activator, which exhibits a great Nrf2-activating potential.
M14594 KI696 KI696 is a high affinity probe that disrupts the Keap1/NRF2 interaction. KI696 is a potent and selective inhibitor of the KEAP1/NRF2 interaction.
M14593 Keap1-Nrf2-IN-1 Keap1-Nrf2-IN-1 is a Keap1 (Kelch-like ECH-associated protein 1)-Nrf2 (nuclear factor erythroid 2-related factor 2) protein-protein interaction inhibitor, and with an IC50 of 43 nM for Keap1 protein.
M14592 CDDO-EA CDDO-EA is an NF-E2 related factor 2/antioxidant response element (Nrf2/ARE) activator.
M14591 (+)-DHMEQ (+)-DHMEQ is an activator of antioxidant transcription factor Nrf2. (+)-DHMEQ is the enantiomer of (-)-DHMEQ. (-)-DHMEQ inhibits NF-kB than its enantiomer (+)-DHMEQ.
M11261 CDDO-Im CDDO Im (RTA-403) is the activator of Nrf2 and PPAR with Ki of 232 nM and 344 nM for PPARα and PPARγ, respectively.
M9604 Kinsenoside Kinsenoside is a main active component isolated from plants of the genus Anoectochilus, and exhibits many biological activities and pharmacological effects.
M9225 4-Octyl Itaconate 4-Octyl Itaconate is a cell-permeable anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.
M9140 Hinokitiol Hinokitiol (β-thujaplicin) is a component of essential oils isolated from Chymacyparis obtusa, reduces Nrf2 expression, and decreases DNMT1 and UHRF1 mRNA and protein expression, with anti-infective, anti-oxidative, and anti-tumor activities.
M8891 AI-1 AI-1 is a negative regulator of Nrf2.




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