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Cat. No. M14594
KI696 Structure
Size Price Availability
5mg USD 590  USD590 4-7 Days
10mg USD 990  USD990 4-7 Days
25mg USD 1990  USD1990 4-7 Days
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Quality Control & Documentation
Biological Activity

KI696 is a high affinity probe that disrupts the Keap1/NRF2 interaction. KI696 is a potent and selective inhibitor of the KEAP1/NRF2 interaction.

Chemical Information
Molecular Weight 550.63
CAS Number 1799974-70-1
Solubility (25°C) DMSO 50 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Katsuya Satoh, et al. J Biochem. Characterization of RecA424 and RecA670 proteins from Deinococcus radiodurans

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Keywords: KI696 supplier, Keap1-Nrf2, inhibitors, activators

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