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CDDO-TFEA (RTA 404; TP-500) is a trifluoroacetamide derivative of CDDO with enhanced ability to cross the blood-brain barrier. CDDO is an Nrf2 activator that inhibits proliferation and induces differentiation and apoptosis in various cancer cells. CDDO-TFEA can enhance Nrf2 expression and signaling in various neurodegenerative disease models.
CDDO-TFEA induces apoptosis and blocks colony formation in Ewing's sarcoma and neuroblastoma cell lines with IC50 values ranging of 85-170 nM.
| Molecular Weight | 572.7 |
| Formula | C33H43F3N2O3 |
| CAS Number | 932730-52-4 |
| Form | Solid |
| Storage | Store at -20°C |
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