All AbMole products are for research use only, cannot be used for human consumption.
Sulforaphane is an orally active inducer of the Keap1/Nrf2/ARE pathway. Sulforaphane inhibits the lipopolysaccharide LPS induced HDAC6, HDAC10 and DNA methyltransferase (DNMT3a) gene expression, whereas up-regulated the expression of DNMT1 gene.Sulforaphane inhibits the global HDAC activity, and suppressed moDCs differentiation from immature to mature DCs through down-regulating the CD40, CD80 and CD86 expression and led further to enhanced phagocytosis of moDCs.Sulforaphane showed a protective role in LPS induced cell apoptosis through suppressing the IRF6 and TGF-ß1 production. Sulforaphane impaired the pro-inflammatory cytokine TNF-α and IL-1ß secretion into the cell culture supernatants that were induced in moDCs by LPS stimulation, whereas Sulforaphane increased the cellular-resident TNF-α accumulation.Sulforaphane plays a protective role against APAP-mediated hepatotoxicity through antioxidant effects mediated by HO-1 induction. Sulforaphane has preventive action in oxidative stress-mediated liver injury. Sulforaphane protected cells against glycative damage by inhibiting the activation of caspase-3 enzyme, reducing the phosphorylation of MAPK signaling pathways (ERK1/2, JNK, and p38), reducing oxidative stress and increasing intracellular GSH levels.
Adv Mater. 2023 Jun 1;e2301257.
Targeted Reprogramming of Vitamin B3 Metabolism as a Nanotherapeutic Strategy towards Chemoresistant Cancers
Sulforaphane purchased from AbMole
Int J Pharm. 2023 Sep 13;645:123389.
Effective myocardial infarction treatment by targeted accumulation of Sulforaphane using porous magnetic silica nanoparticles
Sulforaphane purchased from AbMole
Biochem Biophys Res Commun. 2022 Mar 2.
Sulforaphane protects myocardium from ischemia-reperfusion injury by regulating CaMKIIN2 and CaMKIIδ
Sulforaphane purchased from AbMole
Sci Total Environ. 2021 Oct 1;789:148029.
The aggravation of allergic airway inflammation with dibutyl phthalate involved in Nrf2-mediated activation of the mast cells
Sulforaphane purchased from AbMole
Food Funct. 2021 Nov 1;12(21):10950-10966.
Physalin B inhibits PDGF-BB-induced VSMC proliferation, migration and phenotypic transformation by activating the Nrf2 pathway
Sulforaphane purchased from AbMole
Environ Pollut. 2020 Apr;259:113812.
Sulforaphane prevents chromium-induced lung injury in rats via activation of the Akt/GSK-3β/Fyn pathway.
Sulforaphane purchased from AbMole
Molecular Weight | 177.29 |
Formula | C6H11NOS2 |
CAS Number | 4478-93-7 |
Solubility (25°C) | DMSO 50 mg/mL Ethanol |
Storage | -20°C, dry, sealed, protect from light |
Related Keap1-Nrf2 Products |
---|
CDDO-TFEA
CDDO-TFEA (RTA 404; TP-500) is a trifluoroacetamide derivative of CDDO with enhanced ability to cross the blood-brain barrier. CDDO is an Nrf2 activator that inhibits proliferation and induces differentiation and apoptosis in various cancer cells. CDDO-TFEA can enhance Nrf2 expression and signaling in various neurodegenerative disease models. |
KI696 isomer
KI696 isomer is the less active isomer of KI696. |
TAT-14
TAT-14 is a 14-mer peptide that acts as Nrf2 activator with an anti-inflammatory effect. |
[D-Asp3]-Microcystin-LR
Microcystin-[D-Asp3]-LR/Microcystin A is a cyanotoxin. |
Keap1-Nrf2 probe
Keap1-Nrf2 probe is a fluorescent Keap1-Nrf2 probe. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.