Sulforaphane inhibits the lipopolysaccharide LPS induced HDAC6, HDAC10 and DNA methyltransferase (DNMT3a) gene expression, whereas up-regulated the expression of DNMT1 gene.Sulforaphane inhibits the global HDAC activity, and suppressed moDCs differentiation from immature to mature DCs through down-regulating the CD40, CD80 and CD86 expression and led further to enhanced phagocytosis of moDCs.Sulforaphane showed a protective role in LPS induced cell apoptosis through suppressing the IRF6 and TGF-ß1 production. Sulforaphane impaired the pro-inflammatory cytokine TNF-α and IL-1ß secretion into the cell culture supernatants that were induced in moDCs by LPS stimulation, whereas Sulforaphane increased the cellular-resident TNF-α accumulation.Sulforaphane plays a protective role against APAP-mediated hepatotoxicity through antioxidant effects mediated by HO-1 induction. Sulforaphane has preventive action in oxidative stress-mediated liver injury.Sulforaphane has the potential to improve cognitive function in patients with schizophrenia.Sulforaphane protected cells against glycative damage by inhibiting the activation of caspase-3 enzyme, reducing the phosphorylation of MAPK signaling pathways (ERK1/2, JNK, and p38), reducing oxidative stress and increasing intracellular GSH levels.
Biochem Biophys Res Commun. 2022 Mar 2.
Sulforaphane protects myocardium from ischemia-reperfusion injury by regulating CaMKIIN2 and CaMKIIδ
Sulforaphane purchased from AbMole
Food Funct. 2021 Nov 1;12(21):10950-10966.
Physalin B inhibits PDGF-BB-induced VSMC proliferation, migration and phenotypic transformation by activating the Nrf2 pathway
Sulforaphane purchased from AbMole
Sci Total Environ. 2021 Oct 1;789:148029.
The aggravation of allergic airway inflammation with dibutyl phthalate involved in Nrf2-mediated activation of the mast cells
Sulforaphane purchased from AbMole
Environ Pollut. 2020 Apr;259:113812.
Sulforaphane prevents chromium-induced lung injury in rats via activation of the Akt/GSK-3β/Fyn pathway.
Sulforaphane purchased from AbMole
Molecular Weight | 177.29 |
Formula | C6H11NOS2 |
CAS Number | 4478-93-7 |
Solubility (25°C) | DMSO 50 mg/mL Ethanol |
Storage | -20°C, dry, sealed, protect from light |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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