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Eriodictyol 7-O-glucoside

Cat. No. M18229
Eriodictyol 7-O-glucoside Structure
Size Price Availability Quantity
5mg USD 380  USD380 In stock
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Quality Control & Documentation
Biological Activity

Eriodictyol 7-O-glucoside

Chemical Information
Molecular Weight 450.39
Formula C21H22O11
CAS Number 38965-51-4
Form Solid
Solubility (25°C) DMSO 90 mg/mL
Storage 4°C, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Alexander M Zakharenko, et al. Biochem Res Int. Simultaneous Determination of 78 Compounds of Rhodiola rosea Extract by Supercritical CO 2-Extraction and HPLC-ESI-MS/MS Spectrometry

[2] Yoshinori Fujimura, et al. J Nat Prod. Eriodictyol-Amplified 67-kDa Laminin Receptor Signaling Potentiates the Antiallergic Effect of O-Methylated Catechin

[3] Ting-Ting Zhu, et al. Plant Sci. Functional characterization of UDP-glycosyltransferases from the liverwort Plagiochasma appendiculatum and their potential for biosynthesizing flavonoid 7-O-glucosides

[4] Xu Jing, et al. Toxicol Appl Pharmacol. Eriodictyol-7-O-glucoside activates Nrf2 and protects against cerebral ischemic injury

[5] Qingwen Hu, et al. Food Chem Toxicol. Eriodictyol-7-O-glucoside, a novel Nrf2 activator, confers protection against cisplatin-induced toxicity

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