ML385 inihbits the activity of the Nrf2 transcription factor by binding to Neh1, a NC-bZIP domain that allows Nrf2 to heterodimerize with small Maf proteins, blocking NRF2 transcriptional activity. Much research has been done on activating Nrf2 because it induces cytoprotective antioxidant genes. However, some cancer cells may use Nrf2 similarly for their survival. Nrf2 is overexpressed in certain cancers such as non-small cell lung cancer (NSCLC) often due to loss of function mutations in KEAP1, which targets Nrf2 for proteasomal degradation. ML385 was found to have anti-tumor activity with specificity and selectivity for NSCLC cells with KEAP1 mutations.
Exp Ther Med. 2022 May;23(5):358.
Leonurine: A compound with the potential to prevent acute lung injury
ML385 purchased from AbMole
Pharm Biol. 2022 Dec;60(1):638-651.
In vivo and in vitro protective effects of shengmai injection against doxorubicin-induced cardiotoxicity
ML385 purchased from AbMole
Food Research International. 2022 Sep 12.
N-3 Polyunsaturated Fatty Acids Protect Esophageal Epithelial Cells from Acid Exposure
ML385 purchased from AbMole
Free Radic Biol Med. 2022 Nov 3;193(Pt 1):459-473.
Sirtuin 7 mitigates renal ferroptosis, fibrosis and injury in hypertensive mice by facilitating the KLF15/Nrf2 signaling
ML385 purchased from AbMole
Front Immunol. 2022 Feb 4;13:847861.
Allicin Improves Intestinal Epithelial Barrier Function and Prevents LPS-Induced Barrier Damages of Intestinal Epithelial Cell Monolayers
ML385 purchased from AbMole
Front Pharmacol . 2022 Jul 18;13:943111.
(±)-5-bromo-2-(5-fluoro-1-hydroxyamyl) Benzoate Protects Against Oxidative Stress Injury in PC12 Cells Exposed to H 2 O 2 Through Activation of Nrf2 Pathway
ML385 purchased from AbMole
Oxid Med Cell Longev. 2022 Apr 16;2022:4505513.
Nrf2-Mediated Ferroptosis Inhibition Exerts a Protective Effect on Acute-on-Chronic Liver Failure
ML385 purchased from AbMole
Med J Chin PLA. 2021 Mar 28;Vol. 46, No. 3.
Anti-aging effects of Schisandrin C on H2O2-induced HaCaT
ML385 purchased from AbMole
Front Oncol. 2021 May 26;11:679816.
Antidiabetic Agent DPP-4i Facilitates Murine Breast Cancer Metastasis by Oncogenic ROS-NRF2-HO-1 Axis via a Positive NRF2-HO-1 Feedback Loop
ML385 purchased from AbMole
Pharmacol Res Perspect. 2021 May;9(3):e00791.
Dexamethasone promotes the endoplasmic reticulum stress response of bone marrow mesenchymal stem cells by activating the PERK-Nrf2 signaling pathway
ML385 purchased from AbMole
Biomed Res Int. 2021 Jun 10;2021:6616547.
Antioral Squamous Cell Carcinoma Effects of Carvacrol via Inhibiting Inflammation, Proliferation, and Migration Related to Nrf2/Keap1 Pathway
ML385 purchased from AbMole
Molecular Weight | 511.59 |
Formula | C29H25N3O4S |
CAS Number | 846557-71-9 |
Solubility (25°C) | DMSO ≥ 30 mg/mL |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
Related Nrf2 Products |
---|
cis-Resveratrol
cis-Resveratrol (cis-RESV, cRes, (Z)-Resveratrol) is the Cis isomer of Resveratrol. Resveratrol is a natural phenolic compound with anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol is an inhibitor of pregnane X receptor (PXR) and an activator of Nrf2 and SIRT1 and may induce apoptosis. |
Nrf2-IN-1
Nrf2-IN-1 is an inhibitor of nuclear factor-erythroid 2-related factor 2 (Nrf2). Nrf2-IN-1 is developed for the research of acute myeloid leukemia (AML). |
NK-252
NK-252 is a potential Nrf2 activator, which exhibits a great Nrf2-activating potential. |
KI696
KI696 is a high affinity probe that disrupts the Keap1/NRF2 interaction. KI696 is a potent and selective inhibitor of the KEAP1/NRF2 interaction. |
Keap1-Nrf2-IN-1
Keap1-Nrf2-IN-1 is a Keap1 (Kelch-like ECH-associated protein 1)-Nrf2 (nuclear factor erythroid 2-related factor 2) protein-protein interaction inhibitor, and with an IC50 of 43 nM for Keap1 protein. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.