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Nrf2-IN-1

Cat. No. M14596
Nrf2-IN-1 Structure
Size Price Availability Quantity
5mg USD 350  USD350 In stock
10mg USD 480  USD480 In stock
25mg USD 680  USD680 In stock
50mg USD 1050  USD1050 In stock
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Quality Control & Documentation
Biological Activity

Nrf2-IN-1 is an inhibitor of nuclear factor-erythroid 2-related factor 2 (Nrf2). Nrf2-IN-1 is developed for the research of acute myeloid leukemia (AML).

Chemical Information
Molecular Weight 383.87
CAS Number 1610022-76-8
Solubility (25°C) DMSO 150 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Wentong Li, et al. Cells Tissues Organs. Death-Associated Protein Kinase 1 Regulates Oxidative Stress in Cardiac Ischemia Reperfusion Injury

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  Catalog
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Keywords: Nrf2-IN-1 supplier, Keap1-Nrf2, inhibitors, activators


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