Free shipping on all orders over $ 500

Omaveloxolone

Cat. No. M10081
Omaveloxolone Structure
Synonym:

RTA-408

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
5mg USD 100  USD100 In stock
10mg USD 150  USD150 In stock
25mg USD 280  USD280 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
Biological Activity

Omaveloxolone (RTA-408) is a member of the synthetic oleanane triterpenoid class of compounds and an activator of nuclear factor erythroid 2 [NF-E2]-related factor 2 (Nrf2). Omaveloxolone (RTA-408) potently increases expression of Nrf2 target genes and reverses IFNγ-mediated suppression of Gclc expression in RAW 264.7 cells. In a panel of eight human tumor cell lines, Omaveloxolone inhibits growth with an average GI50 value of 260 nM and induces apoptosis.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 554.71
Formula C33H44F2N2O3
CAS Number 1474034-05-3
Purity 99.71%
Solubility DMSO 90 mg/mL
Storage at -20°C
References

[1] Brandon L Probst, et al. PLoS One. RTA 408, A Novel Synthetic Triterpenoid with Broad Anticancer and Anti-Inflammatory Activity

[2] Devorah C Goldman, et al. Radiat Res. The triterpenoid RTA 408 is a robust mitigator of hematopoietic acute radiation syndrome in mice

[3] Scott A Reisman, et al. Radiat Res. Topical application of the synthetic triterpenoid RTA 408 protects mice from radiation-induced dermatitis

[4] Scott A Reisman, et al. Arch Dermatol Res. Topical application of the synthetic triterpenoid RTA 408 activates Nrf2 and induces cytoprotective genes in rat skin

Related Nrf2 Products
Kinsenoside

Kinsenoside is a main active component isolated from plants of the genus Anoectochilus, and exhibits many biological activities and pharmacological effects.

4-Octyl Itaconate

4-Octyl Itaconate is a cell-permeable anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.

Hinokitiol

Hinokitiol (β-thujaplicin) is a component of essential oils isolated from Chymacyparis obtusa, reduces Nrf2 expression, and decreases DNMT1 and UHRF1 mRNA and protein expression, with anti-infective, anti-oxidative, and anti-tumor activities.

Brusatol

Brusatol (Brutasol) is a plant-derived natural quassinoid that exhibits broad cytotoxicity in cancer cultures (IC50 <1 μM against 457 cancer cell lines) by inhibiting de novo synthesis of cellular proteins (Effective conc.

ML385

ML385 inihbits the activity of the Nrf2 transcription factor by binding to Neh1, a CNC-bZIP domain that allows Nrf2 to heterodimerize with small Maf proteins, blocking NRF2 transcriptional activity.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Omaveloxolone, RTA-408 supplier, Nrf2, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.