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Ezetimibe ketone

Cat. No. M21431

All AbMole products are for research use only, cannot be used for human consumption.

 Ezetimibe ketone Structure
Synonym:

EZM-K

Size Price Availability
5mg USD 70  USD70 Out of stock
10mg USD 110  USD110 Out of stock
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Quality Control & Documentation
Biological Activity

Ezetimibe ketone (EZM-K) is a phase I metabolite of Ezetimibe. Ezetimibe is an NPC1L1 inhibitor, and Ezetimibe inhibits intestinal cholesterol absorption by preventing the absorption of cholesterol by the NPC1L1 protein. It is a potent Nrf2 activator.

Chemical Information
Molecular Weight 407.41
Formula C24H19F2NO3
CAS Number 191330-56-0
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Shizuya Yamashita, et al. Curr Atheroscler Rep. Pemafibrate, a New Selective PPARα Modulator: Drug Concept and Its Clinical Applications for Dyslipidemia and Metabolic Diseases

[2] Shipeng Zhan, et al. Cochrane Database Syst Rev. Ezetimibe for the prevention of cardiovascular disease and all-cause mortality events

[3] Marc Hellerstein, et al. Curr Opin Lipidol. Reverse cholesterol transport fluxes

[4] Miyako Kishimoto, et al. J Med Invest. Efficacy of ezetimibe as monotherapy or combination therapy in hypercholesterolemic patients with and without diabetes

[5] Yong S K Moon, et al. Drugs Today (Barc). Ezetimibe and fenofibrate combination therapy for mixed hyperlipidemia

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  Catalog
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Keywords: Ezetimibe ketone, EZM-K supplier, Keap1-Nrf2, inhibitors, activators

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