Inhibitor/Activator
| Cat.No. | Name | Information |
|---|---|---|
| M3988 | Sulforaphane | Sulforaphane is an orally active inducer of the Keap1/Nrf2/ARE pathway. Sulforaphane promotes the transcription of tumor-suppressing proteins and effectively inhibits the activity of HDACs. Sulforaphane (SFN) extracted from broccoli sprout is an agent with potent anti-oxidant and anti-inflammatory activity. |
| M8692 | ML385 | ML385 was a specific nuclear factor erythroid 2-related factor 2 (NRF2) inhibitor with an IC50 of 1.9 μM. ML385 inhibits Nrf2 transcription factor activity by binding to Neh1. |
| M10081 | Omaveloxolone | Omaveloxolone (RTA 408) is a first-in-class antioxidant inflammatory modulator (AIM) that activates Nrf2 and inhibits nitric oxide (NO). Omaveloxolone inhibits osteoclastogenesis by inhibiting the STING-dependent NF-κb signaling pathway. |
| M8710 | Brusatol | Brusatol (NSC 172924) is a plant-derived natural quassinoid that exhibits broad cytotoxicity in cancer cultures (IC50 <1 μM against 457 cancer cell lines) by inhibiting de novo synthesis of cellular proteins (Effective conc. <50 nM in A549 cells), including NRF2. |
| M9604 | Kinsenoside | Kinsenoside is a main active component isolated from plants of the genus Anoectochilus, and exhibits many biological activities and pharmacological effects. Kinsenoside and Nrf2 depend on the protection of nuclear cells (NPCs), which significantly reduces their ability to survive. Kinsenoside Active NPC Medium AKT-ERK1/2-Nrf2 Signal passage, Prevent physical decline, aging, harmonious physical function impairment. |
| M9225 | 4-Octyl Itaconate | 4-Octyl Itaconate is a cell-permeable anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1. |
| M9140 | Hinokitiol | Hinokitiol (β-thujaplicin) is a component of essential oils isolated from Chymacyparis obtusa, reduces Nrf2 expression, and decreases DNMT1 and UHRF1 mRNA and protein expression, with anti-infective, anti-oxidative, and anti-tumor activities. |
| M8891 | AI-1 | AI-1 is a negative regulator of Nrf2. |
| M8404 | Danshensu | Danshensu is an active component of Salvia miltiorrhiza (Danshen) that suppresses the formation of reactive oxygen species, inhibits platelet adhesion and aggregation, and protects myocardium against ischemia. |
| M7182 | RA 839 | RA 839 is a nrf2 activator; inhibits Nrf2/Keap1 interaction (Kd = 6 μM). RA 839 suppresses LPS-induced iNOS and nitric oxide expression in macrophages. Anti-inflammatory. |
| M6976 | ML 334 | ML334 (LH601A) is a inhibitor of Keap1- Nrf2 interaction. |
| M4589 | Luteolin | Luteolin (Luteoline) is a flavanoid that can induce cell apoptosis and cell cycle arrest in several cancer cell lines. Luteolin (Luteoline) is also a potent Nrf2 inhibitor. |
| M4588 | Astilbin | Astilbin is a flavonoid that enhances NRF2 activation. Astilbin also inhibited TNF-α expression and NF-κB activation. |
| M4072 | Ginsenoside-Rh3 | Ginsenoside Rh3 is a bacterial metabolite of Ginsenoside Rg5. Ginsenoside Rh3 induces Nrf2 activation in human retinal cells. |
| M56830 | KI696 isomer | KI696 isomer is the less active isomer of KI696. |
| M52372 | [D-Asp3]-Microcystin-LR | Microcystin-[D-Asp3]-LR/Microcystin A is a cyanotoxin. |
| M52371 | Keap1-Nrf2 probe | Keap1-Nrf2 probe is a fluorescent Keap1-Nrf2 probe. |
| M50196 | BAY-3605349 | BAY-3605349 is an orally active Kelch-like ECH-associated protein 1 (KEAP1) activator as well as Nrf2 inhibitor for tumor-related studies. |
| M49741 | Nrf2/HO-1 activator 1 | Nrf2/HO-1 activator 1 is a potent Nrf2/HO-1 activator, neuroprotective agent. |
| M49646 | Nrf2/HO-1 activator 2 | Nrf2/HO-1 activator 2 , difluoro-substituted derivative, is a potent Nrf2/HO-1 activator. |
| M42737 | Nrf2-IN-3 | Nrf2-IN-3 is a Nrf2 inhibitor. |
| M42736 | Nrf2 activator-3 | Nrf2 activator-3 is a potent Nrf2 activator. |
| M42735 | Keap1-Nrf2-IN-16 | Keap1-Nrf2-IN-16 is a biological active peptide. |
| M42734 | Nrf2 activator-8 | Nrf2 activator-8 is a Nrf2 activator (EC50=37.9 nM). |
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