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AI-1

Cat. No. M8891
AI-1 Structure
Size Price Availability Quantity
5mg USD 100  USD100 In stock
10mg USD 180  USD180 In stock
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Quality Control & Documentation
Biological Activity

AI-1 is a negative regulator of Nrf2. AI-1 promotes Nrf2 activation via the covalent modification of Kelch-like ECH-associated protein 1 (Keap1). Biochemical studies indicate that an aromatic chloride present within the AI-1 molecule undergoes a nucleophilic aromatic substitution reaction with cysteine thiols of Keap1.

Chemical Information
Molecular Weight 265.69
Formula C13H12ClNO3
CAS Number 75483-04-4
Solubility (25°C) DMSO: ≥15 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Hosohama-Saito K, et al. PLoS One. Involvement of luxS in Biofilm Formation by Capnocytophaga ochracea.

[2] Gao R, et al. Appl Environ Microbiol. Genome-wide RNA sequencing analysis of quorum sensing-controlled regulons in the plant-associated Burkholderia glumae PG1 strain.

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Keywords: AI-1 supplier, Keap1-Nrf2, inhibitors, activators


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