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AI-1 is a negative regulator of Nrf2. AI-1 promotes Nrf2 activation via the covalent modification of Kelch-like ECH-associated protein 1 (Keap1). Biochemical studies indicate that an aromatic chloride present within the AI-1 molecule undergoes a nucleophilic aromatic substitution reaction with cysteine thiols of Keap1.
| Molecular Weight | 265.69 |
| Formula | C13H12ClNO3 |
| CAS Number | 75483-04-4 |
| Solubility (25°C) | DMSO: ≥15 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Keap1-Nrf2 Products |
|---|
| CDDO-TFEA
CDDO-TFEA (RTA 404; TP-500) is a trifluoroacetamide derivative of CDDO with enhanced ability to cross the blood-brain barrier. CDDO is an Nrf2 activator that inhibits proliferation and induces differentiation and apoptosis in various cancer cells. CDDO-TFEA can enhance Nrf2 expression and signaling in various neurodegenerative disease models. |
| KI696 isomer
KI696 isomer is the less active isomer of KI696. |
| TAT-14
TAT-14 is a 14-mer peptide that acts as Nrf2 activator with an anti-inflammatory effect. |
| [D-Asp3]-Microcystin-LR
Microcystin-[D-Asp3]-LR/Microcystin A is a cyanotoxin. |
| Keap1-Nrf2 probe
Keap1-Nrf2 probe is a fluorescent Keap1-Nrf2 probe. |
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