About 30 results found for searched term "AI-1" (0.028 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M3358 | Procainamide hydrochloride | Sodium Channel |
| Procaine amide hydrochloride; SP 100 hydrochloride | ||
| Procainamide hydrochloride is a sodium channel blocker, and also a DNA methyltransferase inhibitor. | ||
| M3640 | BAY 57-1293 | Anti-infection |
| Pritelivir; AIC316 | ||
| BAY 57-1293 is a potent helicase primase inhibitor that exhibites antiviral effect on herpes simplex virus (HSV) with IC50 of 20 nM for both HSV-1 and HSV-2. | ||
| M1622 | Secukinumab | IL Receptor/Related |
| AIN457; CAS# 1229022-83-6 | ||
| Secukinumab (AIN457) is a high-affinity monoclonal antibody against interleukin (IL-17A). Secukinumab (AIN457) is the first-in-class anti-IL-17 agent to be used in studies of plaque psoriasis, ankylosing spondylitis, and psoriatic arthritis. | ||
| M4098 | Saikosaponin-B1 | Smo |
| Saikosaponin B1 is a bioactive ingredient of Bupleurum chinense with anticancer activity. Saikosaponin B1 significantly inhibits tumor growth in medulloblastoma (MB) models by targeting SMO to inhibit Hedgehog pathway. | ||
| M4152 | Daidzin | Dehydrogenase |
| Daidzoside; NPI-031D; Daidzein 7-O-glucoside | ||
| Daidzin is an isoflavone that has anti-oxidant, anti-carcinogenic, and anti-atherosclerotic activities; directly inhibits mitochondrial aldehyde dehydrogenase 2 (IC50 = 80 nM) and is an effective anti-dipsotropic isoflavone. | ||
| M5217 | AI-10-49 | Others |
| AI-10-49 is a selective inhibitor of the binding of CBFβ-SMMHC to RUNX1 with IC50 of 260 nM. | ||
| M5293 | Protease Inhibitor Cocktail (EDTA-Free, 100X in DMSO) | Inhibitor Cocktails |
| Protease inhibitor cocktails are used in mammalian cell lysates or tissue extracts to increase protein stability. | ||
| M6420 | AIM-100 | Others |
| AIM100 | ||
| AIM-100 is a potent and selective Ack1 (TNK2) inhibitor (IC50 = 22 nM). | ||
| M7346 | T16Ainh-A01 | Chloride Channel |
| T16Ainh-A01 is a Ca2+-activated Cl- channel transmembrane protein 16A (TMEM16A) inhibitor. | ||
| M8891 | AI-1 | Keap1-Nrf2 |
| AI-1 is a negative regulator of Nrf2. | ||
| M9332 | Apilimod | Others |
| STA-5326; LAM-002A free base; AIT-101 | ||
| Apilimod is a potent IL-12/IL-23 inhibitor, and it is also a cell permeable small molecule which specifically inhibits PIKfyve with an IC50 of 14 nM in an in vitro kinase assay. | ||
| M9481 | ML092 | Parasite |
| Cruzain-IN-1; ML-092 | ||
| ML092 (Cruzain-IN-1) is a selective, covalent and reversible Cruzain inhibitor, with IC50 of 10 nM. | ||
| M11306 | Etelcalcetide hydrochloride | Calcium-sensing Receptor |
| AMG 416 hydrochloride; KAI-4169 hydrochloride | ||
| Etelcalcetide Hydrochloride (AMG 416 Hydrochloride) is a synthetic peptide that acts as a calcium-sensitive receptor (CaSR) activator. Etelcalcetide hydrochloride effectively reduces parathyroid hormone (PTH) concentration in patients with secondary hyperparathyroidism undergoing hemodialysis. | ||
| M13406 | Deacetylase Inhibitor Cocktail (100X) | Inhibitor Cocktails |
| AbMole Deacetylase Inhibitor Cocktail is a synergistic combination of chemicals designed to preserve the acetylation state of proteins. AbMole Deacetylase Inhibitor Cocktail (100X) is provided as 1 mL vial. Each vial contains 1 mL 70% DMSO with the following components: Trichostatin A (40 μM), EX-527 (1 mM), Nicotinamide (400 mM), and Sodium Butyrate (200 mM). | ||
| M13529 | BAI1 | Bcl-2 |
| BAI1 is a selective and allosteric inhibitor of BAX, an apoptosis regulator. BAI1 directly binds to BAX and allosterically inhibits BAX activation. BAI1 has the potential for the research of diseases mediated by BAX-dependent cell death. | ||
| M13628 | EOAI3402143 | Deubiquitinase |
| EOAI3402143 is a deubiquitinase (DUB) inhibitor, which inhibits dose-dependently inhibits Usp9x/Usp24 and Usp5. | ||
| M13816 | Procainamide | DNA Methyltransferase |
| Procaine amide; SP 100 | ||
| Procainamide is a specific and potent inhibitor of DNA methyltransferase 1 (DNMT1). Procainamide is a Class 1A antiarrhythmic agent. Procainamide has the potential for the research of cancer and arrhythmias. | ||
| M18106 | 4β,12-dihydroxyguaian-6,10-diene | Others |
| 4β,12-dihydroxyguaian-6,10-diene | ||
| M18123 | 1αH,5αH-guaia-6-ene-4β,10β-diol | Others |
| 1αH,5αH-guaia-6-ene-4β,10β-diol | ||
| M20601 | TAI-1 | Microtubule |
| TAI-1 is a first-in-class, potent, specific, orally active Hec1 inhibitor that disrupts the Hec1-Nek2 protein interaction. | ||
| M24563 | Telimomab aritox | Others |
| T101-ricin A chain immunotoxin T101-RTA | ||
| Telimomab aritox (T101-ricin A chain immunotoxin) is a mouse monoclonal antibody that linked to the A chain of the ricin protein. Telimomab aritox can be used as an immunosuppressive agent. | ||
| M25270 | Conatumumab | TNF Receptor |
| AMG 655; TRAIL-R2 mAb Human Anti-TNFRSF10B Recombinant Antibody | ||
| Conatumumab (AMG 655) is a human monoclonal agonist antibody against human death receptor 5 (DR5, TRAILR2) (Kd: 1 nM for the long form of DR5, 0.8 nM for the short form of DR5). Conatumumab induces apoptosis via caspase activation. Conatumumab can be used in the research of cancers. . | ||
| M27595 | Enmetazobactam | Antibiotic |
| AAI101 | ||
| Enmetazobactam (AAI101) is an extended-spectrum β-lactamase inhibitor, against many resistant Gram-negative pathogens. | ||
| M28060 | AI-10-47 | Others |
| AI-10-47 is a small molecule inhibitor of CBFβ-RUNX binding, with an IC50 of 3.2 μM. | ||
| M28089 | Etelcalcetide | Calcium-sensing Receptor |
| AMG 416; KAI-4169 | ||
| Etelcalcetide (AMG 416) is a synthetic peptide as an activator of the calcium sensing receptor (CaSR). Etelcalcetide is effective in lowering parathyroid hormone (PTH) concentrations in patients receiving dialysis with secondary hyperparathyroidism receiving hemodialysis. | ||
| M28405 | Pritelivir mesylate hydrate | Anti-infection |
| AIC316 mesylate hydrate; BAY 57-1293 mesylate hydrate | ||
| Pritelivir mesylate hydrate (BAY 57-1293 mesylate hydrate), an inhibitor of the viral helicase-primase complex, exhibits antiviral activity in vitro and in animal models of herpes simplex virus (HSV) infection. Pritelivir mesylate hydrate is active against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) with the IC50 of 0.02 μM against HSV1-2. | ||
| M28406 | Pritelivir mesylate | Anti-infection |
| AIC316 mesylate; BAY 57-1293 mesylate | ||
| Pritelivir mesylate (BAY 57-1293 mesylate), an inhibitor of the viral helicase-primase complex, exhibits antiviral activity in vitro and in animal models of herpes simplex virus (HSV) infection. Pritelivir mesylate is active against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) with the IC50 of 0.02 μM against HSV1-2. | ||
| M29410 | Benzgalantamine | AChR/AChE |
| GLN-1062; Memogain; ALPHA-1062 | ||
| Benzgalantamine (GLN-1062) is a pro-agent of galantamine, it is used for the research for Alzheimer’s disease. | ||
| M29525 | SIAIS164018 | PROTAC |
| SIAIS164018 is a PROTAC-based ALK and EGFR degrader, which is designed from Brigatinib, with IC50 value of 2.5 nM and 6.6 nM for ALK and ALK G1202R, respectively. SIAIS164018 strongly inhibits cancer cells migration and invasion, causes G1 cell cycle arrest and induces apoptosis. SIAIS164018 exhibits better property than Brigatinib. | ||
| M29559 | SIAIS178 | PROTAC |
| SIAIS178 is a potent and selective BCR-ABL degrader based on PROTAC technology with an IC50 of 24 nM. SIAIS178 causes effective degradation of BCR-ABL protein by recruiting Von Hippel-Lindau (VHL) E3 ubiquitin ligase. SIAIS178 has anticancer activity. | ||
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