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AIM-100 is a potent Ack1 (TNK2) inhibitor (IC50 = 22 nM). AIM-100 exhibits selectivity for Ack1 over ABL1, BTK, Lck and LYN; exhibits no inhibition of 25 other kinases. AIM-100 suppresses phosphorylation of Tyr267 of the androgen receptor in prostate cancer cells. AIM-100 also suppresses growth of radioresistant castration-resistant prostate cancer in xenograft tumors in mice.
| Molecular Weight | 371.43 |
| Formula | C23H21N3O2 |
| CAS Number | 873305-35-2 |
| Form | Solid |
| Solubility (25°C) | DMSO 37.14 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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