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BAY 57-1293

Cat. No. M3640
BAY 57-1293 Structure
Synonym:

Pritelivir; AIC316

Size Price Availability Quantity
10mM*1mL in DMSO USD 54  USD54 In stock
5mg USD 48  USD48 In stock
10mg USD 68  USD68 In stock
50mg USD 140  USD140 In stock
100mg USD 240  USD240 In stock
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Quality Control & Documentation
Biological Activity

BAY 57-1293 directly inhibits the ATPase activity of the viral helicase-primase enzyme complex in a dose-dependent manner. BAY 57-1293 shows potent antiviral activity against acyclovir resistant HSV mutants. BAY 57-1293 reduces Aβ and P-tau induced by herpes simplex virus type 1 in vero cells. BAY 57-1293 significantly reduces time to healing, prevents rebound of disease after cessation of treatment and, most importantly, reduces frequency and severity of recurrent disease.

Protocol (for reference only)
Cell Experiment
Cell lines
Preparation method
Concentrations
Incubation time
Animal Experiment
Animal models Murine and rat lethal challenge models of disseminated herpes, a murine zosteriform spread model of cutaneous disease, a murine ocular herpes model.
Formulation 0.5 mg/kg or 15 mg/kg
Dosages Suspended in 0.5% tylose in PBS
Administration p.o.
Chemical Information
Molecular Weight 402.49
Formula C18H18N4O3S2
CAS Number 348086-71-5
Form Solid
Solubility (25°C) DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Kleymann G, et al. Nat Med. New helicase-primase inhibitors as drug candidates for the treatment of herpes simplex disease.

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Keywords: BAY 57-1293, Pritelivir; AIC316 supplier, Anti-infection, inhibitors, activators


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