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RA 839 is a nrf2 activator; inhibits Nrf2/Keap1 interaction (Kd = 6 μM). RA 839 suppresses LPS-induced iNOS and nitric oxide expression in macrophages. Anti-inflammatory.
| Molecular Weight | 452.57 |
| Formula | C25H28N2O4S |
| CAS Number | 1832713-02-6 |
| Solubility (25°C) | DMSO 45 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Liu and Hermann. J Biol Chem. Characterization of ionomycin as a calcium ionophore.
| Related Keap1-Nrf2 Products |
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CDDO-TFEA (RTA 404; TP-500) is a trifluoroacetamide derivative of CDDO with enhanced ability to cross the blood-brain barrier. CDDO is an Nrf2 activator that inhibits proliferation and induces differentiation and apoptosis in various cancer cells. CDDO-TFEA can enhance Nrf2 expression and signaling in various neurodegenerative disease models. |
| KI696 isomer
KI696 isomer is the less active isomer of KI696. |
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Keap1-Nrf2 probe is a fluorescent Keap1-Nrf2 probe. |
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