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4-Octyl Itaconate

Cat. No. M9225
4-Octyl Itaconate Structure
Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
100mg USD 100  USD100 In stock
200mg USD 175  USD175 In stock
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Quality Control
Biological Activity

4-Octyl Itaconate is a cell-permeable Itaconate derivative. 4-Octyl Itaconate is protective against lipopolysaccharide-induced lethality in vivo and decreases cytokine production.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 242.31
Formula C13H22O4
CAS Number 3133-16-2
Purity 99.68%
Solubility DMSO ≥ 25 mg/mL
Storage at -20°C
References

[1] Mills EL, et al. Nature. Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: 4-Octyl Itaconate supplier, Nrf2, inhibitors

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