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CDDO-EA

Cat. No. M14592
CDDO-EA Structure
Synonym:

CDDO ethyl amide; TP319; RTA 405

Size Price Availability Quantity
5mg USD 255  USD255 In stock
10mg USD 465  USD465 In stock
25mg USD 825  USD825 In stock
50mg USD 1380  USD1380 In stock
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Quality Control & Documentation
Biological Activity

CDDO-EA is an NF-E2 related factor 2/antioxidant response element (Nrf2/ARE) activator.

Chemical Information
Molecular Weight 518.73
CAS Number 932730-51-3
Solubility (25°C) DMSO ≥ 34 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Xia Lei, et al. The novel Nrf2 activator CDDO-EA attenuates cerebral ischemic injury by promoting microglia/macrophage polarization toward M2 phenotype in mice

[2] Cun-Xin Zhang, et al. Protective effect of CDDO-ethyl amide against high-glucose-induced oxidative injury via the Nrf2/HO-1 pathway

[3] Yonas Getachew, et al. The Synthetic Triterpenoid RTA 405 (CDDO-EA) Halts Progression of Liver Fibrosis and Reduces Hepatocellular Carcinoma Size Resulting in Increased Survival in an Experimental Model of Chronic Liver Injury

[4] N Suh, et al. Synthetic triterpenoids, CDDO-Imidazolide and CDDO-Ethyl amide, induce chondrogenesis

[5] Cliona Stack, et al. Triterpenoids CDDO-ethyl amide and CDDO-trifluoroethyl amide improve the behavioral phenotype and brain pathology in a transgenic mouse model of Huntington's disease

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Keywords: CDDO-EA, CDDO ethyl amide; TP319; RTA 405 supplier, Nrf2, inhibitors, activators

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