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CDDO-EA

Cat. No. M14592
CDDO-EA Structure
Synonym:

CDDO ethyl amide; TP319; RTA 405

Size Price Availability Quantity
5mg USD 255  USD255 In stock
10mg USD 465  USD465 In stock
25mg USD 825  USD825 In stock
50mg USD 1380  USD1380 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

CDDO-EA is an NF-E2 related factor 2/antioxidant response element (Nrf2/ARE) activator.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 518.73
Formula
CAS Number 932730-51-3
Purity >99%
Solubility DMSO ≥ 34 mg/mL
Storage at -20°C
References

[1] Xia Lei, et al. The novel Nrf2 activator CDDO-EA attenuates cerebral ischemic injury by promoting microglia/macrophage polarization toward M2 phenotype in mice

[2] Cun-Xin Zhang, et al. Protective effect of CDDO-ethyl amide against high-glucose-induced oxidative injury via the Nrf2/HO-1 pathway

[3] Yonas Getachew, et al. The Synthetic Triterpenoid RTA 405 (CDDO-EA) Halts Progression of Liver Fibrosis and Reduces Hepatocellular Carcinoma Size Resulting in Increased Survival in an Experimental Model of Chronic Liver Injury

[4] N Suh, et al. Synthetic triterpenoids, CDDO-Imidazolide and CDDO-Ethyl amide, induce chondrogenesis

[5] Cliona Stack, et al. Triterpenoids CDDO-ethyl amide and CDDO-trifluoroethyl amide improve the behavioral phenotype and brain pathology in a transgenic mouse model of Huntington's disease

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Keywords: CDDO-EA, CDDO ethyl amide; TP319; RTA 405 supplier, Nrf2, inhibitors

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