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(-)-Alkannin

Cat. No. M30227

All AbMole products are for research use only, cannot be used for human consumption.

(-)-Alkannin Structure

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Quality Control & Documentation
Biological Activity

(-)-Alkannin, found in Alkanna tinctoria, is used as a food coloring. (-)-Alkannin shows anticancer activity, arrests cell cycle, and induces apoptosis. (-)-Alkannin improves hepatic inflammation in a Rho-kinase pathway.

Chemical Information
Molecular Weight 288.3
Formula C16H16O5
CAS Number 517-88-4
Form Solid
Solubility (25°C) DMSO 33.33 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Toru Hosoi, et al. Mol Pharmacol. Alkannin Attenuates Amyloid β Aggregation and Alzheimer's Disease Pathology

[2] Kirandeep Kaur, et al. Chin Herb Med. Pharmacological and analytical aspects of alkannin/shikonin and their derivatives: An update from 2008 to 2022

[3] Yaowen Wang, et al. Evid Based Complement Alternat Med. Alkannin Inhibits the Development of Ovarian Cancer by Affecting miR-4461

[4] Mingxin Chang, et al. Front Pharmacol. Alkannin-Induced Oxidative DNA Damage Synergizes With PARP Inhibition to Cause Cancer-Specific Cytotoxicity

[5] Qianwen Zheng, et al. Biochem Pharmacol. Alkannin induces cytotoxic autophagy and apoptosis by promoting ROS-mediated mitochondrial dysfunction and activation of JNK pathway

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Keywords: (-)-Alkannin supplier, Apoptosis, inhibitors, activators

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