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Itaconate-alkyne

Cat. No. M43962

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Itaconate-alkyne Structure
Synonym:

ITalk

Size Price Availability Quantity
10mg USD 320  USD320 In stock
25mg USD 640  USD640 In stock
50mg USD 920  USD920 In stock
100mg USD 1280  USD1280 In stock
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Quality Control & Documentation
Biological Activity

Itaconate-alkyne is a specific bioorthogonal probe and functional analog of Itaconation, which has similar anti-inflammatory activity to Itaconic acid, and can label the true target of Itaconic acid for quantitative and localized Itaconic acid chemistry proteomics analysis in living cells. In addition, Itaconate-alkyne is also a click chemistry containing an Alkyne moiety that undergoes a copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing an Azide moiety.

Chemical Information
Molecular Weight 238.28
Formula C13H18O4
CAS Number 2454181-83-8
Form Solid
Solubility (25°C) DMSO >100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Chao Wei, et al. Cell Death Differ. Itaconate protects ferroptotic neurons by alkylating GPx4 post stroke

[2] Wei Qin, et al. J Am Chem Soc. Chemoproteomic Profiling of Itaconation by Bioorthogonal Probes in Inflammatory Macrophages

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Keywords: Itaconate-alkyne, ITalk supplier, inhibitors, activators

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