All AbMole products are for research use only, cannot be used for human consumption.
BMPR1A/ALK-3/CD292 protein is expressed in the epithelium during branching morphogenesis. It is a type I receptor for bone morphogenetic proteins (BMPs) which belong to the transforming growth factor beta (TGF-β) superfamily. BMPR1A/ALK-3 plays an essential role in the formation of embryonic ventral abdominal wall, and abrogation of BMP signaling activity due to gene mutations in its signaling components could be one of the underlying causes of omphalocele at birth. The type IA BMP receptor, ALK-3 was specifically required at mid-gestation for normal development of the trabeculae, compact myocardium, interventricular septum, and endocardial cushion.
Recombinant human BMPR1A/ALK-3/CD292 consists of 141 amino acids and has a predicted molecular mass of 15.7 kDa. A DNA sequence encoding the extracellular domain (Met 1-Arg 152) of human ALK3 was fused with a polyhistidine tag at the C-terminus.
Measured by its ability to inhibit BMP4-induced alkaline phosphatase production by MC3T3E1 mouse preosteoblast cells, the ED50 for this effect is 20-120 ng/mL.
Accession: NP_004320.2
Endotoxin < 1 EU/µg
Apparent Molecular Weight: 28-33 kDa, reducing conditions
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
| Form | Lyophilized powder |
| Solubility (25°C) | Reconstitute the lyophilized powder in distilled water up to 100 μg/ml. |
| Storage | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. |
| Related Recombinant Proteins Products |
|---|
| Recombinant Mouse VEGF164 Protein (Baculovirus-Insect)
Vascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF) and VEGF-A, is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, inhibiting apoptosis and tumor growth. VEGF-A protein is also a vasodilator that increases microvascular permeability. |
| Recombinant Human MMP13 Protein (E. coli, N-His)
The MMP-13 protein plays a role in the degradation of extracellular matrix proteins, especially fibrillar collagen, fibronectin, TNC, and ACAN. It cleaves triple-helical collagen, preferentially cleaves type II collagen, and can also target other collagen types. |
| Recombinant Human PSA/KLK3 Protein (Mammalian, 244AA, C-6His)
Recombinant Human PSA/KLK3 is a member of serine proteases having diverse physiological functions. Kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. |
| Recombinant Human CA125 Protein (Mammalian, C-6His)
CA125 is a mucin protein that may be found in type I transmembrane or secreted forms that are used monitor the progress of epithelial ovarian cancer therapy. CA125 binds galectin-1 on immune cells and enhances its expression on tumor cells. CA125-expressing tumors adhere to NK cells, down-regulate CD16 and suppress NK response, which may promote immune evasion. |
| Recombinant Mouse Neuroserpin Protein (HEK293, C-His)
Neuroserpin, also known as SERPINI1, is a secreted protein that belongs to the serpin family. Neuroserpin is a serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. Neuroserpin may be involved in the formation or reorganization of synaptic connections, as well as synaptic plasticity in the adult nervous system. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.
