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ALK Anaplastic lymphoma kinase


Cat.No.  Name Information
M1743 Ensartinib Ensartinib (X-396) is a potent and highly specific ALK small molecule tyrosine kinase inhibitor.
M1873 LDN-193189 LDN-193189 is a highly potent small molecule inhibitor of bone morphogenetic protein (BMP) type I receptors ALK2 and ALK3.
M1720 AP26113 (Brigatinib) AP26113 (Brigatinib) is a highly potent ALK inhibitor with IC50 of 0.6 nM.
M2075 LDK378 LDK378 is a highly selective, orally bioavailable ALK inhibitor with IC50 of 0.15 nM.
M1794 SB431542 SB-431542 is a potent and selective inhibitor of the transforming growth factor-β (TGF-β) type I receptor activin receptor-like kinase ALK5 (IC50 = 94 nM).
M21110 Con B-1 ConB-1 is a strongly selective ALK inhibitor with low toxicity to normal cells.
M20040 WAY-270947 WAY-270947 is a ALK5 inhibitor.
M14878 Ensartinib dihydrochloride Ensartinib dihydrochloride (X-396 dihydrochloride) is a potent and dual ALK/MET inhibitor with IC50s of <0.4 nM and 0.74 nM, respectively.
M14877 ALK inhibitor 1 ALK inhibitor 1 (compound 17) is a potent pyrimidin ALK inhibitor. ALK inhibitor 1 is a potent inhibitor of testis-specific serine/threonine kinase 2 (TSSK2; IC50=31 nM) and focal adhesion kinase (FAK; IC50=2 nM).
M9397 MS4078 MS4078 is a PROTAC degrader of ALK which potently decreases cellular levels of oncogenic active ALK fusion proteins in SU-DHL-1 lymphoma and NCI-H2228 lung cancer cells.
M6186 Repotrectinib (TPX-0005) Repotrectinib (TPX-0005) is a potential best-in-class ALK/ROS1/TRK inhibitor against SRC, wild-type WT ALK, The IC50 values of ALK G1202R and ALK L1196M were 5.3 nM, 1.01 nM, 1.26 nM and 1.08 nM, respectively.
M6168 Ceritinib (LDK378) dihydrochloride Ceritinib dihydrochloride (LDK378 dihydrochloride) is potent inhibitor against ALK with IC50 of 0.2 nM, shows 40- and 35-fold selectivity against IGF-1R and InsR, respectively.
M5613 Entrectinib (RXDX-101) Entrectinib (RXDX-101) is an orally bioavailable pan-TrkA/B/C, ROS1 and ALK inhibitor with IC50 ranging between 0.1 and 1.7 nM.
M5320 Crizotinib hydrochloride Crizotinib is inhibitor of the c-Met kinase and the NPM-ALK. Crizotinib inhibited cell proliferation in ALK-positive ALCL cells (IC50s=30 nM). Crizotinib is useful in treatment of anaplastic large-cell lymphoma.
M5309 ALK-IN-1 ALK-IN-1 is an analog of AP26113 which is a potent and selective ALK inhibitor. It is also an inhibitor of EGFR.
M4984 CEP-37440 CEP-37440 is a novel potent and selective Dual FAK/ALK inhibitor with IC50 s of 2.3 nM (FAK) and 120 nM(ALK cellular IC50 in 75% human plasma).
M4811 CH5424802 HCl CH5424802 HCl is a potent ALK inhibitor with IC50 of 1.9 nM, sensitive to L1196M mutation.
M3975 PF-06463922 Lorlatinib (PF-06463922) is an oral active, selective, brain osmotic and ATP-competitive ROS1/ALK inhibitor. The Ki of Lorlatinib for ROS1, wild-type ALK and ALKL1196M were <0.025 nM, <0.07 nM and 0.7 nM, respectively. Lorlatinib has anticancer activity.
M3889 LDN-214117 LDN-214117 is a potent and selective ALK2 inhibitor with IC50 of 22 nM and >100 fold selectivity for ALK5.
M3781 NVP-TAE684 NVP-TAE684 is a highly potent and selective small-molecule ALK inhibitor, which blocked the growth of ALCL-derived and ALK-dependent cell lines with IC(50) values between 2 and 10 nM.
M2859 ML347 ML347 is a selective BMP receptor inhibitor with IC50 of 32 nM for ALK2, >300-fold selectivity over ALK3. Also inhibits ALK1 activity with IC50 of 46 nM.
M2806 LDN-212854 LDN-212854 is a potent and selective BMP receptor inhibitor with IC50 of 1.3 nM for ALK2, about 2-, 66-, 1641-, and 7135-fold selectivity over ALK1, ALK3, ALK4, and ALK5, respectively.
M2805 LDN-193189 Tetrahydrochloride LDN193189 Tetrahydrochloride is the hydrochloride salt of LDN193189, which is a selective BMP signaling inhibitor, and inhibits the transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 of 5 nM and 30 nM, respectively, 200-fold selectivity for BMP versus TGF-β.
M2789 K02288 K02288 is a potent, and selective type I BMP receptor inhibitor with IC50 of 1.1, 1.8, 6.4 nM for ALK2, ALK1 and ALK6, showing weaker inhibition on other ALKs (3, 4, 5) and ActRIIA.
M2201 TSR-011 TSR-011 is a potent, orally available ALK inhibitor.

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