| Cat.No. | Name | Information |
|---|---|---|
| M1743 | X-376 | X-376 is a potent and highly specific ALK small molecule tyrosine kinase inhibitor with IC50 of 0.61 nM. |
| M1873 | LDN-193189 | LDN-193189 is a highly potent small molecule inhibitor of bone morphogenetic protein (BMP) type I receptors ALK2 and ALK3. |
| M1720 | AP26113 (Brigatinib) | AP26113 (Brigatinib) is a highly potent ALK inhibitor with IC50 of 0.6 nM. |
| M2075 | LDK378 | LDK378 is a highly selective, orally bioavailable ALK inhibitor with IC50 of 0.15 nM. |
| M1794 | SB431542 | SB-431542 is a potent and selective inhibitor of the transforming growth factor-β (TGF-β) type I receptor activin receptor-like kinase ALK5 (IC50 = 94 nM). |
| M1950 | ASP3026 | ASP3026 is a novel and selective inhibitor for the ALK kinase. |
| M2789 | K02288 | K02288 is a potent, and selective type I BMP receptor inhibitor with IC50 of 1.1, 1.8, 6.4 nM for ALK2, ALK1 and ALK6, showing weaker inhibition on other ALKs (3, 4, 5) and ActRIIA. |
| M2647 | DMH1 | DMH1 is a selective BMP receptor inhibitor with IC50 of 107.9 nM for ALK2, exhibiting no inhibition on AMPK, ALK5, KDR (VEGFR-2) or PDGFR. |
| M2201 | TSR-011 | TSR-011 is a potent, orally available ALK inhibitor. |
| M2186 | UK 383367 | UK 383367 is a potent and selective BMP-1 (procollagen C-proteinase; PCP) inhibitor with IC50 of 44 nM. |
| M2109 | AZD3463 | AZD3463 is a novel ALK/IGF1R inhibitor with IC50 value of 22 nM. |
| M1946 | CEP-28122 | CEP-28122 is a highly potent and selective orally active ALK inhibitor. |
| M1942 | CH5424802 | CH5424802 is a highly selective, orally active and potent ALK inhibitor with IC50 of 1.9 nM. |
| M1932 | GSK1838705A | GSK1838705A is a small-molecule kinase inhibitor that inhibits IGF-IR and the insulin receptor with IC50s of 2.0 and 1.6 nmol/L, respectively. |
| M1859 | RepSox (ALK5 Inhibitor II) | RepSox (ALK5 Inhibitor II) is a potent and ATP-competitive inhibitor of the TGF-β type I receptor ALK5 (IC50 values are 0.004 and 0.023 μM for ALK5 autophosphorylation and ALK5 binding respectively). |
| M49468 | NVL-655 | NVL-655 is a novel, brain-permeable, selective ALK inhibitor with antitumor activity. For Ba/F3 CLIP1-LTK cells, NVL-655 has an IC50 of 2.7 nM. It can be used in studies related to ALK-positive non-small cell lung cancer (NSCLC). |
| M45164 | APG-2449 | APG-2449 is an orally active, potent ALK/ROS1/FAK inhibitor with anti-tumor activity in a mouse model of non-small cell lung cancer (NSCLC). |
| M43471 | ALK2-IN-5 | ALK2-IN-5, pyrazolopyrimidine compound, is an ALK2 inhibitor. |
| M43470 | J-1048 | J-1048 is an activin receptor-like kinase 5 (ALK5) inhibitor. |
| M43469 | CPD-1224 | CPD-1224 is an orally active derivative of ALK inhibitors to cereblon ligands. |
| M43468 | Ack1 inhibitor 1 | Ack1 inhibitor 1 is a potent, selective, and orally active inhibitor of ACK1 kinase with an IC50 value of 2.1 nM. |
| M31136 | Conteltinib | Conteltinib (CT-707) is a potent second-generation mesenchymal lymphoma kinase (ALK) tyrosine kinase inhibitor (TKI) with antitumor activity for studies related to hepatocellular carcinoma (HCC). |
| M29632 | M4K2234 | M4K2234 (compound 26b) is an ALK2 inhibitor. M4K2234 inhibits ALK2 and ALK5 with IC50s of 5 and 2144 nM, respectively. M4K2234 can be used as a chemical probe for ALK1 and ALK2 protein kinases. M4K2234 can be used for the research of cancer. |
| M29459 | ZX-29 | ZX-29 is a potent and selective ALK inhibitor with an IC50 of 2.1 nM, 1.3 nM and 3.9 nM for ALK, ALK L1196M and ALK G1202R mutations, respectively. ZX-29 is inactive against EGFR. ZX-29 induces apoptosis by inducing endoplasmic reticulum (ER) stress and overcomes cell resistance caused by an ALK mutation. ZX-29 also induces protective autophagy and has antitumor effect. |
| M29396 | Ficonalkib | Ficonalkib is a potent inhibitor of Anaplastic lymphoma kinase (ALK), the tyrosine kinase receptor. Ficonalkib, can be used as an antineoplastic agent. |
| M28969 | Envonalkib citrate | Envonalkib citrate is a potent and orally active inhibitor of ALK, with IC50s of 1.96 nM, 35.1 nM, and 61.3 nM for WT and mutated L1196M and G1269S-ALK. Envonalkib citrate can be used for the research of non-small cell lung cancer. |
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