| Cat.No. | Name | Information |
|---|---|---|
| M1743 | X-376 | X-376 is a potent and highly specific ALK small molecule tyrosine kinase inhibitor with IC50 of 0.61 nM. |
| M1873 | LDN-193189 | LDN-193189 is a highly potent small molecule inhibitor of bone morphogenetic protein (BMP) type I receptors ALK2 and ALK3. |
| M1720 | AP26113 (Brigatinib) | AP26113 (Brigatinib) is a highly potent ALK inhibitor with IC50 of 0.6 nM. |
| M2075 | LDK378 | LDK378 is a highly selective, orally bioavailable ALK inhibitor with IC50 of 0.15 nM. |
| M1794 | SB431542 | SB-431542 is a potent and selective inhibitor of the transforming growth factor-β (TGF-β) type I receptor activin receptor-like kinase ALK5 (IC50 = 94 nM). |
| M1950 | ASP3026 | ASP3026 is a novel and selective inhibitor for the ALK kinase. |
| M28954 | Iruplinalkib | Iruplinalkib (WX-0593) is a potent, selective, and orally active inhibitor of ALK and ROS1 tyrosine kinase. Iruplinalkib (WX-0593) shows favorable safety and promising antitumor activity in advanced NSCLC with ALK or ROS1 rearrangement. |
| M28756 | JH-VIII-157-02 | JH-VIII-157-02 is a structural analogue of alectinib, acts as an ALK inhibitor, and shows an IC50 of 2 nM for echinoderm microtubule-associated protein-like 4-ALK (EML4-ALK) G1202R in cells. |
| M28499 | ALK kinase inhibitor-1 | ALK kinase inhibitor-1 is an anaplastic lymphoma kinase (ALK) inhibitor. |
| M28270 | Ensartinib | Ensartinib (X-396) is a potent and dual ALK/MET inhibitor with IC50s of <0.4 nM and 0.74 nM, respectively. |
| M24696 | Ascrinvacumab | Ascrinvacumab (PF-03446962) is a human IgG2 monoclonal antibody targets ALK-1. Ascrinvacumab shows binding efficiency with human ALK1 with a Kd value of 7 nM. Ascrinvacumab can be used for the research of hepatocellular carcinoma (HCC). |
| M21110 | Con B-1 | ConB-1 is a strongly selective ALK inhibitor with low toxicity to normal cells. |
| M20040 | WAY-270947 | WAY-270947 is a ALK5 inhibitor. |
| M14878 | Ensartinib dihydrochloride | Ensartinib dihydrochloride (X-396 dihydrochloride) is a potent and dual ALK/MET inhibitor with IC50s of <0.4 nM and 0.74 nM, respectively. |
| M14877 | ALK inhibitor 1 | ALK inhibitor 1 (compound 17) is a potent pyrimidin ALK inhibitor. ALK inhibitor 1 is a potent inhibitor of testis-specific serine/threonine kinase 2 (TSSK2; IC50=31 nM) and focal adhesion kinase (FAK; IC50=2 nM). |
| M14147 | TPX-0131 | The CNS-penetrant ALK kinase inhibitor TPX-0131 was more potent in vitro against WT-ALK and many ALK resistance mutations than all five approved ALK inhibitors. |
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