All AbMole products are for research use only, cannot be used for human consumption.
Crizotinib is inhibitor of the c-Met kinase and the NPM-ALK. Crizotinib inhibited cell proliferation in ALK-positive ALCL cells (IC50s=30 nM). Crizotinib is useful in treatment of anaplastic large-cell lymphoma.
| Molecular Weight | 486.8 |
| Formula | C21H23Cl3FN5O |
| CAS Number | 1415560-69-8 |
| Solubility (25°C) | ≥ 4.6 mg/mL in DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related ALK Products |
|---|
| ALKBH5-IN-3
ALKBH5-IN-3 is a potent and selective ALKBH5 inhibitor, with an IC50 of 21 nM. ALKBH5-IN-3 could efficiently stabilize ALKBH5 in HepG2 cells and increase m6A level in intact cells. |
| F-1
F-1 is a potent ALK and ROS1 dual inhibitor, suppresses phospho-ALK and its relative downstream signaling pathways, with IC50 values of 2.1 nM, 2.3 nM, 1.3 nM and 3.9 nM for ALKWT, ROS1WT, ALKL1196M and ALKG1202R, respectively. |
| TL13-22
TL13-22 is a negative control for TL13-12 and a potent ALK inhibitor with an IC50 of 0.54 nM. |
| TL13-110
TL13-110 is a negative control for TL13-112 and a potent ALK inhibitor with an IC50 of 0.34 nM. |
| ALK inhibitor 2
ALK inhibitor 2 is a potent pyrimidin ALK inhibitor. |
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