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Crizotinib hydrochloride

Cat. No. M5320
Crizotinib hydrochloride Structure
Synonym:

PF-02341066 hydrochloride

Size Price Availability
10mg USD 60  USD60 4-7 Days
50mg USD 120  USD120 4-7 Days
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Quality Control & Documentation
Biological Activity

Crizotinib is inhibitor of the c-Met kinase and the NPM-ALK. Crizotinib inhibited cell proliferation in ALK-positive ALCL cells (IC50s=30 nM). Crizotinib is useful in treatment of anaplastic large-cell lymphoma.

Chemical Information
Molecular Weight 486.8
Formula C21H23Cl3FN5O
CAS Number 1415560-69-8
Solubility (25°C) ≥ 4.6 mg/mL in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Dietrich MF, et al. J Thorac Oncol. Response to Crizotinib/Erlotinib Combination in a Patient with a Primary EGFR-Mutant Adenocarcinoma and a Primary c-met-Amplified Adenocarcinoma of the Lung.

[2] Doherty KR, et al. Toxicol Appl Pharmacol. Multi-parameter in vitro toxicity testing of crizotinib, sunitinib, erlotinib, and nilotinib in human cardiomyocytes.

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  Catalog
Abmole Inhibitor Catalog




Keywords: Crizotinib hydrochloride, PF-02341066 hydrochloride supplier, ALK, inhibitors, activators


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