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Con B-1

Cat. No. M21110
Con B-1 Structure
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Biological Activity

ConB-1 is a strongly selective ALK inhibitor with low toxicity to normal cells.

Chemical Information
Molecular Weight 770.38
Formula C38H52ClN7O6S
CAS Number 2415537-51-6
Solubility (25°C) N/A
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Manqian Cha, et al. Toxins (Basel). Adsorbents Reduce Aflatoxin M1 Residue in Milk of Healthy Dairy Cow Exposed to Moderate Level Aflatoxin B1 in Diet and Its Exposure Risk for Humans

[2] Kellie Toohey, et al. BMC Cancer. The impact of high-intensity interval training exercise on breast cancer survivors: a pilot study to explore fitness, cardiac regulation and biomarkers of the stress systems

[3] Jiamin Wu, et al. Animals (Basel). Resveratrol Attenuates Aflatoxin B1-Induced ROS Formation and Increase of m6A RNA Methylation

[4] Ying Tang, et al. Anal Chim Acta. Novel quartz crystal microbalance immunodetection of aflatoxin B1 coupling cargo-encapsulated liposome with indicator-triggered displacement assay

[5] Patrick P Carriere, et al. Int J Oncol. Cinnamtannin B-1 inhibits cell survival molecules and induces apoptosis in colon cancer

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Abmole Inhibitor Catalog

Keywords: Con B-1 supplier, ALK, inhibitors, activators

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