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DMH1

Cat. No. M2647
DMH1 Structure
Synonym:

dorsomorphin homolog 1

Size Price Availability Quantity
5mg USD 55  USD55 In stock
10mg USD 88  USD88 In stock
50mg USD 300  USD300 In stock
100mg USD 500  USD500 In stock
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Quality Control & Documentation
Biological Activity

DMH1 is a selective BMP receptor inhibitor with IC50 of 107.9 nM for ALK2, exhibiting no inhibition on AMPK, ALK5, KDR (VEGFR-2) or PDGFR.

Customer Product Validations & Biological Datas
Source Adv Healthc Mater (2017). Figure 1. DMH1
Method RT-PCR
Cell Lines hMSCs
Concentrations 50 μm
Incubation Time 0, 3, and 14 d
Results To evaluate the necessity of ERK1/2 phosphorylation on osteogenic gene expression, PD98059, a selective MEK1/2 inhibitor was used to treat hMSCs cultured on Col-GAG and MC-GAG and quantitative reverse-transcriptase polymerase chain reactions (RT-PCR) was performed in the same manner as the DMH1 experiment.
Chemical Information
Molecular Weight 380.44
Formula C24H20N4O
CAS Number 1206711-16-1
Solubility (25°C) DMSO 22 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Yue Sheng, et al. DMH1 (4-[6-(4-isopropoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline) inhibits chemotherapeutic drug-induced autophagy

[2] Xin Xie, et al. DMH1 increases glucose metabolism through activating Akt in L6 rat skeletal muscle cells

[3] Jijun Hao, et al. DMH1, a small molecule inhibitor of BMP type i receptors, suppresses growth and invasion of lung cancer

[4] M Diana Neely, et al. DMH1, a highly selective small molecule BMP inhibitor promotes neurogenesis of hiPSCs: comparison of PAX6 and SOX1 expression during neural induction

[5] Ada Ao, et al. DMH1, a novel BMP small molecule inhibitor, increases cardiomyocyte progenitors and promotes cardiac differentiation in mouse embryonic stem cells

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Keywords: DMH1, dorsomorphin homolog 1 supplier, ALK, inhibitors, activators


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