Free shipping on all orders over $ 500

MS4078

Cat. No. M9397

All AbMole products are for research use only, cannot be used for human consumption.

MS4078 Structure
Size Price Availability Quantity
1mg USD 60  USD60 In stock
5mg USD 120  USD120 In stock
10mg USD 185  USD185 In stock
25mg USD 350  USD350 In stock
50mg USD 540  USD540 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

MS4078 is a PROTAC degrader of ALK which potently decreases cellular levels of oncogenic active ALK fusion proteins in SU-DHL-1 lymphoma and NCI-H2228 lung cancer cells, with a Kd of 19 nM for binding affinity to ALK. MS4078 potently reduces the ALK fusion protein levels and inhibits the ALK auto-phosphorylation and down-steam STAT3 phosphorylation in both SU-DHL-1 and NCI-H2228 cells in a concentration-dependent manner. In NCI-H2228 cells, MS4078 reduces the EML4-ALK protein levels with similar DC50 value of 59 ± 16 nM after 16-hour treatment. At the 100 nM concentration, NCI-H2228 cells reduces more than 90% of EML4-ALK protein levels

Chemical Information
Molecular Weight 914.47
Formula C45H52ClN9O8S
CAS Number 2229036-62-6
Solubility (25°C) DMSO ≥ 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Zhang C, et al. Eur J Med Chem. Proteolysis Targeting Chimeras (PROTACs) of Anaplastic Lymphoma Kinase (ALK).

Related ALK Products
F-1

F-1 is a potent ALK and ROS1 dual inhibitor, suppresses phospho-ALK and its relative downstream signaling pathways, with IC50 values of 2.1 nM, 2.3 nM, 1.3 nM and 3.9 nM for ALKWT, ROS1WT, ALKL1196M and ALKG1202R, respectively.

TL13-22 

TL13-22 is a negative control for TL13-12 and a potent ALK inhibitor with an IC50 of 0.54 nM.

TL13-110 

TL13-110 is a negative control for TL13-112 and a potent ALK inhibitor with an IC50 of 0.34 nM.

ALK inhibitor 2 

ALK inhibitor 2 is a potent pyrimidin ALK inhibitor.

NVL-655 TFA

NVL-655 (ALK-IN-27) TFA is a novel, brain-permeable, selective ALK inhibitor with antitumor activity. For Ba/F3 CLIP1-LTK cells, NVL-655 (ALK-IN-27) TFA has an IC50 of 2.7 nM. It can be used in studies related to ALK-positive non-small cell lung cancer (NSCLC).

  Catalog
Abmole Inhibitor Catalog




Keywords: MS4078 supplier, ALK, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.



Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.