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Ensartinib dihydrochloride

Cat. No. M14878
Ensartinib dihydrochloride Structure
Synonym:

X-396 dihydrochloride

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Quality Control & Documentation
Biological Activity

Ensartinib dihydrochloride (X-396 dihydrochloride) is a potent and dual ALK/MET inhibitor with IC50s of <0.4 nM and 0.74 nM, respectively.

Chemical Information
Molecular Weight 634.36
CAS Number 2137030-98-7
Solubility (25°C) DMSO 35.71 mg/mL
Water 33.33 mg/mL
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

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Keywords: Ensartinib dihydrochloride, X-396 dihydrochloride supplier, ALK, inhibitors, activators

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