Free shipping on all orders over $ 500


Cat. No. M1743
Ensartinib Structure


Size Price Availability Quantity
2mg USD 110  USD110 In stock
5mg USD 230  USD230 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Ensartinib (X-396) is a potent and highly specific ALK small molecule tyrosine kinase inhibitors (TKIs). In Ambit kinome screens, cell growth inhibition studies, and surrogate kinase assays, Ensartinib (X-396) was more potent inhibitors of ALK but less potent inhibitors of MET compared to PF-02341066. Ensartinib (X-396) displayed potent antitumor activity in vivo with favorable pharmacokinetic and toxicity profiles.

Product Citations
Customer Product Validations & Biological Datas
Source Munich Industrial University (2018). Figure 36. X-396 (AbMole BioScience)
Method Kinase binding of small molecule inhibitors
Cell Lines BT-474 cells, Caki-1 cells, KM-12 and HEK-293 cells
Concentrations 1 μM
Incubation Time 24 h
Results Notably, the photosensitizing effect of small molecule inhibitors can also be used for photodynamic therapy of cancer.
Source Science (2017). Figure 4. X-396 (Abmole Bioscience)
Method Cell viability and proliferation assays
Cell Lines A-431 and ACHN cells
Concentrations 50 nM
Incubation Time 72 h
Results Regardless of whether or not EGFR carried an activating mutation, the combination was always more effective in inhibiting cell viability and proliferation than any one drug alone.
Chemical Information
Molecular Weight 547.41
Formula C25H25Cl2FN6O3
CAS Number 1365267-27-1
Solubility (25°C) DMSO ≥ 22 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Lovly CM et al. Cancer Res. Insights into ALK-driven cancers revealed through development of novel ALK tyrosine kinase inhibitors.

Related ALK Products

ALK2-IN-5, pyrazolopyrimidine compound, is an ALK2 inhibitor.


J-1048 is an activin receptor-like kinase 5 (ALK5) inhibitor.


CPD-1224 is an orally active derivative of ALK inhibitors to cereblon ligands.

Ack1 inhibitor 1

Ack1 inhibitor 1 is a potent, selective, and orally active inhibitor of ACK1 kinase with an IC50 value of 2.1 nM.


Conteltinib (CT-707) is a potent second-generation mesenchymal lymphoma kinase (ALK) tyrosine kinase inhibitor (TKI) with antitumor activity for studies related to hepatocellular carcinoma (HCC).

Abmole Inhibitor Catalog

Keywords: Ensartinib, X-396 supplier, ALK, inhibitors, activators

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.