About 13 results found for searched term "Sirtuin" (0.128 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M4678 | Fisetin | Sirtuin |
| Fustel | ||
| Fisetin (Fustel) is a potent sirtuin activating compound (STAC) and an agent that modulates sirtuins. | ||
| M4896 | Nicotinamide | Sirtuin |
| Vitamin B3; Nicotinic acid amide; Niacinamide | ||
| Nicotinamide is an active component of coenzymes NAD and NADP, and also act as an inhibitor of sirtuins. Nicotinamide plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. | ||
| M7868 | JFD00244 | Others |
| JFD00244 is a SIRT (sirtuin, human silent information regulator) inhibitor. | ||
| M9876 | UBCS039 | Sirtuin |
| UBCS 039 | ||
| UBCS039 is the first synthetic, specific Sirtuin 6 (SIRT6) activator, inducing autophagy in human tumor cells, with an EC50 of 38 μM. | ||
| M10109 | SRT2183 | Sirtuin |
| SRT-2183 | ||
| SRT2183 is a selective activator of Sirtuin-1 (SIRT1) with EC1.5 value of 0.36 μM. | ||
| M10970 | SRT 1460 | Sirtuin |
| SRT 1460 is a potent Sirtuin-1 (SIRT1) agonist EC1.5 The value is 2.9 μM. | ||
| M13734 | MC3482 | Sirtuin |
| MC3482 is a specific sirtuin5 (SIRT5) inhibitor. | ||
| M13735 | SIRT5 inhibitor 1 | Sirtuin |
| SIRT5 inhibitor 1 is a potent Human Sirtuin 5 deacylase inhibitor, with an IC50 of 0.11 μM. | ||
| M20020 | CL-59089 | Sirtuin |
| CL-59089 is a sirtuin modulator. | ||
| M20212 | WAY-616312 | Sirtuin |
| WAY-616312 is a sirtuin modulator. | ||
| M27669 | E1231 | Sirtuin |
| 1-{4-[2-(5-Methylfuran-2-yl)quinoline-4-carbonyl]piperazin-1-yl}ethan-1-one | ||
| E1231 is an orally active activator of Sirtuin 1 (SIRT1) (EC50=0.83 μM), to modulate cholesterol and lipid metabolism. E1231 interactes with SIRT1 (KD=9.61 μM) and deacetylated liver X receptor-alpha (LXRα), and increases ATP-binding cassette transporter A1 (ABCA1) expression. E1231 also reduces atherosclerotic plaque development in ApoE-/- mice model. E1231 can be used for research in cholesterol and lipid disorder-related diseases. | ||
| M38950 | Tanshindiol C | Histone Methyltransferase |
| Tanshindiol C is a S-adenosylmethionine-competitive EZH2 (Histone Methyltransferase) inhibitor with an IC50 of 0.55 μM for inhibiting the methyltransferase activity. Tanshindiol C is also an activator of both Nrf2 and Sirtuin 1 (Sirt1) in macrophages. | ||
| M41604 | Z26395438 | Sirtuin |
| Z26395438 is a potent Sirtuin-1 inhibitor, with an IC50 value of 1.6 μM. | ||
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