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UBCS039

Cat. No. M9876
UBCS039 Structure
Synonym:

UBCS 039

Size Price Availability Quantity
5mg USD 175 In stock
10mg USD 265 In stock
25mg USD 545 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

UBCS039 is an synthetic SIRT6 activator, with EC50 of 38 μM. UBCS039 induces deacetylation of SIRT6-targeted histone H3 sites in human cancer cells. UBCS039-mediated activation of autophagy was strictly dependent on SIRT6 deacetylating activity since the catalytic mutant H133Y failed to activate autophagy.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 247.29
Formula C16H13N3
CAS Number 358721-70-7
Purity >99%
Solubility DMSO 60 mg/mL
Storage at -20°C
References

Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells
Sara Iachettini, et al. Cell Death Dis. 2018 Sep 24;9(10):996. PMID: 30250025.

Structural Basis of Sirtuin 6 Activation by Synthetic Small Molecules
Weijie You, et al. Angew Chem Int Ed Engl. 2017 Jan 19;56(4):1007-1011. PMID: 27990725.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: UBCS039, UBCS 039 supplier, Sirtuin, inhibitors

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