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Inhibitors
| Cat.No. | Name | Information |
|---|---|---|
| M4896 | Nicotinamide | Nicotinamide is an active component of coenzymes NAD and NADP, and also act as an inhibitor of sirtuins. Nicotinamide plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. |
| M1824 | SRT1720 Hydrochloride | SRT1720 Hydrochloride is a selective small molecule activator of SIRT1 that is 1,000-fold more potent than resveratrol (EC1.5 = 0.16 versus 46.2 µM, respectively). SRT1720 increased the activity of SIRT1 and AMPKα phosphorylation at Ser485 via the cAMP-protein kinase A (PKA) pathway. |
| M20828 | NRD167 | NRD167 is a potent and selective SIRT5 inhibitor. |
| M20666 | Crocin I | Crocin I (Gardenia yellow) is an active member of crocin, increases mRNA expression of SIRT3, and acts as an orally active antidepressant agent |
| M20624 | SRT3025 HCl | SRT3025 is an orally available small molecule activator of the SIRT1 enzyme. |
| M20212 | WAY-616312 | WAY-616312 is a sirtuin modulator |
| M20020 | CL-59089 | CL-59089 is a sirtuin modulator |
| M13736 | SIRT-IN-3 | SIRT-IN-3 is a potent SIRT inhibitor, with an IC50 of 17 μM for SIRT1. SIRT-IN-3 shows about 4-fold and 14-fold selectivity for SIRT1 over SIRT2 and SIRT3, respectively (IC50 of 74 μM and 235 μM for SIRT2 and SIRT3, respectively). |
| M13735 | SIRT5 inhibitor 1 | SIRT5 inhibitor 1 is a potent Human Sirtuin 5 deacylase inhibitor, with an IC50 of 0.11 μM. |
| M13734 | MC3482 | MC3482 is a specific sirtuin5 (SIRT5) inhibitor. |
| M11201 | Nicotinamide riboside | Nicotinamide riboside is a precursor to nadir with oral activity that increases NAD levels and activates SIRT1 and SIRT3. Nicotinamide riboside is a source of vitamin B3 (niacin) that enhances oxidative metabolism and prevents metabolic abnormalities induced by a high-fat diet. Nicotinamide riboside can reduce cognitive degradation in transgenic mouse models of Alzheimer's disease. |
| M11030 | SRT 1720 | SRT 1720 is a potent activator of the human SIRT1, EC1.5 The value is 0.16 μM and simultaneously inhibits SIRT2 and SIRT3, EC1.5 The values are 37 μM and > 300 μM, respectively. |
| M10970 | SRT 1460 | SRT 1460 is a potent Sirtuin-1 (SIRT1) agonist EC1.5 The value is 2.9 μM. |
| M10295 | CAY10602 | CAY10602 is a SIRT1 activator, which suppresses the NF-κB-dependent induction of TNF-α by lipopolysaccharide in THP-1 cells dose-dependently. |
| M10109 | SRT2183 | SRT2183 is a selective activator of Sirtuin-1 (SIRT1) with EC1.5 value of 0.36 μM. |
| M9876 | UBCS039 | UBCS039 is an synthetic SIRT6 activator, with EC50 of 38 μM. |
| M9697 | Nicotinamide Riboside Chloride | Nicotinamide Riboside Chloride is a pyridine-nucleoside form of vitamin B3 that functions as a precursor to nicotinamide adenine dinucleotide or NAD+. |
| M9177 | SirReal2 | SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM. |
| M9148 | SRT2104 | SRT2104 is a selective brain-permeable activator of SIRT1. |
| M8978 | 3-TYP | 3-TYP is a selective SIRT3 inhibitor, more potent over SIRT1 and SIRT2, with IC50 values of 88 nM, 92 nM, 16 nM for SITR1, SIRT2, SIRT3, respectively. |
| M8488 | Ophiopogonin D' | Ophiopogonin D', isolated from the tuber of Ophiopogon japonicus, is a rare naturally occurring C29 steroid glycoside. Ophiopogonin D' has cytotoxic activity against two human tumor cell lines mG-63 and SNU387. Ophiopogonin D' can induce necrotic apoptosis of prostate cancer LNCaP cells by activating RIPK1. IC50 were 3.09 μM and 3.63 μM, respectively. SIRT1 is activated in a dose-dependent manner by Ophiopogonin D'. |
| M6414 | AGK 2 | AGK 2 is a selective SIRT2 inhibitor. |
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