| Cat.No. | Name | Information |
|---|---|---|
| M11030 | SRT 1720 | SRT 1720 is a potent activator of the human SIRT1, EC1.5 The value is 0.16 μM and simultaneously inhibits SIRT2 and SIRT3, EC1.5 The values are 37 μM and > 300 μM, respectively. |
| M8978 | 3-TYP | 3-TYP is a selective SIRT3 inhibitor, more potent over SIRT1 and SIRT2, with IC50 values of 88 nM, 92 nM, 16 nM for SITR1, SIRT2, SIRT3, respectively. |
| M6254 | OSS_128167 | OSS_128167 is a specific SIRT6 inhibitor with IC50 values of 89, 1578 and 751 μM for SIRT6, SIRT1 and SIRT2, respectively. |
| M5265 | Thiomyristoyl | Thiomyristoyl is a potent and specific SIRT2 inhibitor with an IC50 of 28 nM. It inhibits SIRT1 with an IC50 value of 98 μM and does not inhibit SIRT3 even at 200 μM. |
| M4896 | Nicotinamide | Nicotinamide is an active component of coenzymes NAD and NADP, and also act as an inhibitor of sirtuins. Nicotinamide plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. |
| M4678 | Fisetin | Fisetin (Fustel) is a potent sirtuin activating compound (STAC) and an agent that modulates sirtuins. |
| M3010 | Sirtinol | Sirtinol is a specific SIRT1 and SIRT2 inhibitor with IC50 of 131 μM and 38 μM, respectively. |
| M2267 | Resveratrol | Resveratrol is a phytoestrogen with antitumor, antioxidant, antiplatelet, anti-inflammatory and antifungal effects. |
| M1824 | SRT1720 Hydrochloride | SRT1720 Hydrochloride is a selective small molecule activator of SIRT1 that is 1,000-fold more potent than resveratrol (EC1.5 = 0.16 versus 46.2 µM, respectively). SRT1720 increased the activity of SIRT1 and AMPKα phosphorylation at Ser485 via the cAMP-protein kinase A (PKA) pathway. |
| M1708 | Selisistat | Selisistat (EX 527) is a potent and selective SIRT1 class III histone deacetylase enzyme inhibitor with an IC50 of 98 nM. |
| M45096 | ADTL-SA1215 | ADTL-SA1215 is a first-in-class, specific small molecule activator of SIRT3 that modulates autophagy in triple-negative breast cancer. |
| M38946 | Cannabisin F | Cannabisin F is a SIRT1 modulator. Cannabisin F, as a hempseed lignanamide, can be used for the research of anti-inflammatory and anti-oxidative. Cannabisin F may be a potential agent of neurodegenerative diseases as modulators of SIRT1/NF-κB and Nrf2. |
| M28898 | SIRT7 inhibitor 97491 | SIRT7 inhibitor 97491, a potent SIRT7 inhibitor with an IC50 of 325 nM, reduces deacetylase activity of SIRT7 in a dose-dependent manner. SIRT7 inhibitor 97491 prevents tumor progression by increasing p53 stability through acetylation at K373/382. SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.. |
| M27669 | E1231 | E1231 is an orally active activator of Sirtuin 1 (SIRT1) (EC50=0.83 μM), to modulate cholesterol and lipid metabolism. E1231 interactes with SIRT1 (KD=9.61 μM) and deacetylated liver X receptor-alpha (LXRα), and increases ATP-binding cassette transporter A1 (ABCA1) expression. E1231 also reduces atherosclerotic plaque development in ApoE-/- mice model. E1231 can be used for research in cholesterol and lipid disorder-related diseases. |
| M20828 | NRD167 | NRD167 (Et-29) is a potent and selective SIRT5 inhibitor with Ki value of 40 nM. |
| M13735 | SIRT5 inhibitor 1 | SIRT5 inhibitor 1 is a potent Human Sirtuin 5 deacylase inhibitor, with an IC50 of 0.11 μM. |
| M11538 | MDL-800 | Mdl-800 is a selective allosteric activator of SIRT6, a member of the SIRT deacetylase family responsible for deacetylation of histone H3K9Ac and H3K56ac, with tumor suppressive activity |
| M11201 | Nicotinamide riboside | Nicotinamide riboside is a precursor to nadir with oral activity that increases NAD levels and activates SIRT1 and SIRT3. Nicotinamide riboside is a source of vitamin B3 (niacin) that enhances oxidative metabolism and prevents metabolic abnormalities induced by a high-fat diet. Nicotinamide riboside can reduce cognitive degradation in transgenic mouse models of Alzheimer's disease. |
| M10970 | SRT 1460 | SRT 1460 is a potent Sirtuin-1 (SIRT1) agonist EC1.5 The value is 2.9 μM. |
| M10295 | CAY10602 | CAY10602 is a SIRT1 activator, which suppresses the NF-κB-dependent induction of TNF-α by lipopolysaccharide in THP-1 cells dose-dependently. |
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