Inhibitors
Cat.No. | Name | Information |
---|---|---|
M4896 | Nicotinamide | Nicotinamide is an active component of coenzymes NAD and NADP, and also act as an inhibitor of sirtuins. Nicotinamide plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. |
M11201 | Nicotinamide riboside | Nicotinamide riboside is a precursor to nadir with oral activity that increases NAD levels and activates SIRT1 and SIRT3. Nicotinamide riboside is a source of vitamin B3 (niacin) that enhances oxidative metabolism and prevents metabolic abnormalities induced by a high-fat diet. Nicotinamide riboside can reduce cognitive degradation in transgenic mouse models of Alzheimer's disease. |
M11030 | SRT 1720 | SRT 1720 is a potent activator of the human SIRT1, EC1.5 The value is 0.16 μM and simultaneously inhibits SIRT2 and SIRT3, EC1.5 The values are 37 μM and > 300 μM, respectively. |
M10970 | SRT 1460 | SRT 1460 is a potent Sirtuin-1 (SIRT1) agonist EC1.5 The value is 2.9 μM. |
M10295 | CAY10602 | CAY10602 is a SIRT1 activator, which suppresses the NF-κB-dependent induction of TNF-α by lipopolysaccharide in THP-1 cells dose-dependently. |
M10109 | SRT2183 | SRT2183 is a selective activator of Sirtuin-1 (SIRT1) with EC1.5 value of 0.36 μM. |
M9876 | UBCS039 | UBCS039 is an synthetic SIRT6 activator, with EC50 of 38 μM. |
M9697 | Nicotinamide Riboside Chloride | Nicotinamide Riboside Chloride is a pyridine-nucleoside form of vitamin B3 that functions as a precursor to nicotinamide adenine dinucleotide or NAD+. |
M9177 | SirReal2 | SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM. |
M9148 | SRT2104 | SRT2104 is a selective brain-permeable activator of SIRT1. |
M8978 | 3-TYP | 3-TYP is a selective SIRT3 inhibitor, more potent over SIRT1 and SIRT2, with IC50 values of 88 nM, 92 nM, 16 nM for SITR1, SIRT2, SIRT3, respectively. |
M8488 | Ophiopogonin D' | Ophiopogonin D', isolated from the tuber of Ophiopogon japonicus, is a rare naturally occurring C29 steroid glycoside. Ophiopogonin D' has cytotoxic activity against two human tumor cell lines mG-63 and SNU387. Ophiopogonin D' can induce necrotic apoptosis of prostate cancer LNCaP cells by activating RIPK1. IC50 were 3.09 μM and 3.63 μM, respectively. SIRT1 is activated in a dose-dependent manner by Ophiopogonin D'. |
M8213 | Salvianolic acid B | Salvianolic acid B is a cell protective antioxidant and free radical scavenger being investigated for a variety of conditions from ischemic heart disorders to Alzheimer′s disease. |
M6254 | OSS_128167 | OSS_128167 is a specific SIRT6 inhibitor with IC50 values of 89, 1578 and 751 μM for SIRT6, SIRT1 and SIRT2, respectively. |
M6241 | Tenovin 6 Hydrochloride | Tenovin-6 Hydrochloride is a water soluble inhibitor of SIRT1 and SIRT2, slightly inhibits HDAC8, and is also a potent activator of p53, with IC50s of 21 μM, 10 μM, 67 μM for SirT1, SirT2, and SirT3, respectively. |
M5265 | Thiomyristoyl | Thiomyristoyl is a potent and specific SIRT2 inhibitor with an IC50 of 28 nM. It inhibits SIRT1 with an IC50 value of 98 μM and does not inhibit SIRT3 even at 200 μM. |
M4896 | Nicotinamide | Nicotinamide is an active component of coenzymes NAD and NADP, and also act as an inhibitor of sirtuins. Nicotinamide plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. |
M4678 | Fisetin | Fisetin (Fustel) is a potent sirtuin activating compound (STAC) and an agent that modulates sirtuins. |
M4674 | Agrimol-B | Agrimol B is a polyphenol derivative isolated from Sepulchrum, which can inhibit fat formation, induce translocation and expression of SIRT1, and reduce the expression of PPARγ. |
M4507 | Scopolin | Scopolin is a coumarin isolated from the roots of Arabidopsis. Scopolin mitigated hepatic steatosis by activating sirT1-mediated signaling cascades. |
M4306 | Ganoderic-acid-D | Ganoderic acid D is a highly oxidized tetracyclic triterpenoid that is the main active ingredient in Ganoderma lucidum. Ganoderic acid D upregulates protein expression for SIRT3 and induces deacetylated cyclophilic protein D (CypD) through SIRT3. Ganoderic acid D inhibits energy reprogramming in colon cancer cells, including glucose uptake, lactate production, pyruvate, and acetyl-Coenzyme production in colon cancer cells. |
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