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Sirtuin Sirtuin

Inhibitors

Cat.No.  Name Information
M4896 Nicotinamide Nicotinamide is an active component of coenzymes NAD and NADP, and also act as an inhibitor of sirtuins. Nicotinamide plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions.
M1824 SRT1720 Hydrochloride SRT1720 Hydrochloride is a selective small molecule activator of SIRT1 that is 1,000-fold more potent than resveratrol (EC1.5 = 0.16 versus 46.2 µM, respectively). SRT1720 increased the activity of SIRT1 and AMPKα phosphorylation at Ser485 via the cAMP-protein kinase A (PKA) pathway.
M20828 NRD167 NRD167 is a potent and selective SIRT5 inhibitor.
M20666 Crocin I Crocin I (Gardenia yellow) is an active member of crocin, increases mRNA expression of SIRT3, and acts as an orally active antidepressant agent
M20624 SRT3025 HCl SRT3025 is an orally available small molecule activator of the SIRT1 enzyme.
M20212 WAY-616312 WAY-616312 is a sirtuin modulator
M20020 CL-59089 CL-59089 is a sirtuin modulator
M13736 SIRT-IN-3 SIRT-IN-3 is a potent SIRT inhibitor, with an IC50 of 17 μM for SIRT1. SIRT-IN-3 shows about 4-fold and 14-fold selectivity for SIRT1 over SIRT2 and SIRT3, respectively (IC50 of 74 μM and 235 μM for SIRT2 and SIRT3, respectively).
M13735 SIRT5 inhibitor 1 SIRT5 inhibitor 1 is a potent Human Sirtuin 5 deacylase inhibitor, with an IC50 of 0.11 μM.
M13734 MC3482 MC3482 is a specific sirtuin5 (SIRT5) inhibitor.
M11201 Nicotinamide riboside Nicotinamide riboside is a precursor to nadir with oral activity that increases NAD levels and activates SIRT1 and SIRT3. Nicotinamide riboside is a source of vitamin B3 (niacin) that enhances oxidative metabolism and prevents metabolic abnormalities induced by a high-fat diet. Nicotinamide riboside can reduce cognitive degradation in transgenic mouse models of Alzheimer's disease.
M11030 SRT 1720 SRT 1720 is a potent activator of the human SIRT1, EC1.5 The value is 0.16 μM and simultaneously inhibits SIRT2 and SIRT3, EC1.5 The values are 37 μM and > 300 μM, respectively.
M10970 SRT 1460 SRT 1460 is a potent Sirtuin-1 (SIRT1) agonist EC1.5 The value is 2.9 μM.
M10295 CAY10602 CAY10602 is a SIRT1 activator, which suppresses the NF-κB-dependent induction of TNF-α by lipopolysaccharide in THP-1 cells dose-dependently.
M10109 SRT2183 SRT2183 is a selective activator of Sirtuin-1 (SIRT1) with EC1.5 value of 0.36 μM.
M9876 UBCS039 UBCS039 is an synthetic SIRT6 activator, with EC50 of 38 μM.
M9697 Nicotinamide Riboside Chloride Nicotinamide Riboside Chloride is a pyridine-nucleoside form of vitamin B3 that functions as a precursor to nicotinamide adenine dinucleotide or NAD+.
M9177 SirReal2 SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.
M9148 SRT2104 SRT2104 is a selective brain-permeable activator of SIRT1.
M8978 3-TYP 3-TYP is a selective SIRT3 inhibitor, more potent over SIRT1 and SIRT2, with IC50 values of 88 nM, 92 nM, 16 nM for SITR1, SIRT2, SIRT3, respectively.
M8488 Ophiopogonin D' Ophiopogonin D', isolated from the tuber of Ophiopogon japonicus, is a rare naturally occurring C29 steroid glycoside. Ophiopogonin D' has cytotoxic activity against two human tumor cell lines mG-63 and SNU387. Ophiopogonin D' can induce necrotic apoptosis of prostate cancer LNCaP cells by activating RIPK1. IC50 were 3.09 μM and 3.63 μM, respectively. SIRT1 is activated in a dose-dependent manner by Ophiopogonin D'.
M6414 AGK 2 AGK 2 is a selective SIRT2 inhibitor.



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