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Mdl-800 is a selective allosteric activator of SIRT6, a member of the SIRT deacetylase family responsible for deacetylation of histone H3K9Ac and H3K56ac, with tumor suppressive activity. Mdl-800 increased SIRT6 deacetylase activity by up to 22 times, leading to cell cycle arrest and inhibiting its proliferation. It also inhibited the growth of hepatocellular carcinoma line BEL7405 xenograft.
| Molecular Weight | 626.3 |
| Formula | C21H16BrCl2FN2O6S2 |
| CAS Number | 2275619-53-7 |
| Solubility (25°C) | DMSO ≥ 10 mg/mL |
| Storage | 2-8°C |
| Related Sirtuin Products |
|---|
| SIRT1-IN-1
SIRT1-IN-1 is a selective SIRT1 inhibitor with an IC50 of 0.205 μM. |
| Sirtuin-1 inhibitor 1
Sirtuin-1 inhibitor 1 is an inhibitor of Sirtuin-1 that plays important roles in obesity-induced diabetes and aging-related diseases. |
| ADTL-SA1215
ADTL-SA1215 is a first-in-class, specific small molecule activator of SIRT3 that modulates autophagy in triple-negative breast cancer. |
| SIRT2/6-IN-1
SIRT2/6-IN-1 is a SIRT6/SIRT2 inhibitor, with IC50s of 106 μM and 114 μM. |
| SIRT6-IN-2
SIRT6-IN-2 is a selective SIRT6 inhibitor (IC50: 34 μM). |
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