Free shipping on all orders over $ 500

SRT1720 Hydrochloride

Cat. No. M1824
SRT1720 Hydrochloride Structure

SRT-1720 Hydrochloride

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mM*1mL In DMSO USD 140 In stock
5mg USD 105 In stock
10mg USD 195 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
Biological Activity

SRT1720 is a selective small molecule activator of SIRT1 that is 1,000-fold more potent than resveratrol (EC1.5 = 0.16 versus 46.2 µM, respectively). SIRT1 belongs to the silent information regulator 2 (Sir2) protein family of enzymes and functions as a NAD(+) -dependent class III histone deacetylase. Treatment of MM cells with SRT1720 inhibited growth and induced apoptosis in MM cells resistant to conventional and bortezomib therapies without significantly affecting the viability of normal cells. Mechanistic studies showed that anti-MM activity of SRT1720 is associated with: (i) activation of caspase-8, caspase-9, caspase-3, poly(ADP) ribose polymerase; (ii) increase in reactive oxygen species; (iii) induction of phosphorylated ataxia telangiectasia mutated/checkpoint kinase 2 signalling; (iv) decrease in vascular endothelial growth factor-induced migration of MM cells and associated angiogenesis; and (v) inhibition of nuclear factor-κB. Blockade of ATM attenuated SRT1720-induced MM cell death. Finally, SRT1720 enhanced the cytotoxic activity of bortezomib or dexamethasone.

Customer Product Validations & Biological Datas
Source Cell Rep (2014). Figure 1.SRT1720
Method gavage
Cell Lines Male C57BL/6J mice
Concentrations 1.33g/kg
Incubation Time
Results The hazard ratio for death was significantly reduced with SRT1720 treatment (HR=0.73, 95% CI (0.59, 0.90)], p=0.0034), indicating a positive effect of SRT1720 on improving lifespan in mice. SRT1720 significantly reduced the average body weight of HFD-fed mice despite no difference in daily caloric intake or food consumption.
Cell Experiment
Cell lines 4T1 cells
Preparation method Cell viability assay.
One day before treatment, 1.5x104 cells per well were seeded in a 96-well plate and allowed to attach overnight. The cells were then treated with varying concentrations of SRT1720 for 24 h. The viable cell number was determined with an MTS assay kit (Promega, Madison, WI, USA).
Concentrations 0~5 μM
Incubation time 24 h
Animal Experiment
Animal models 4T1 cells tumor-bearing mice model
Formulation water
Dosages 100 mg/kg 5 times per week
Administration orally
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 506.02
Formula C25H23N7OS.HCl
CAS Number 1001645-58-4
Purity 100%
Solubility DMSO ≥38 mg/mL
Storage at -20°C

SRT1720, a SIRT1 activator, promotes tumor cell migration, and lung metastasis of breast cancer in mice.
Suzuki K, et al. Oncol Rep. 2012 Jun;27(6):1726-32. PMID: 22470132.

SIRT1 activation by small molecules: kinetic and biophysical evidence for direct interaction of enzyme and activator.
Dai H, et al. J Biol Chem. 2010 Oct 22;285(43):32695-703. PMID: 20702418.

SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1.
Pacholec M, et al. J Biol Chem. 2010 Mar 12;285(11):8340-51. PMID: 20061378.

Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes.
Milne JC, et al. Nature. 2007 Nov 29;450(7170):712-6. PMID: 18046409.

Related Sirtuin Products

SRT2183 is a selective activator of Sirtuin-1 (SIRT1) with EC1.5 value of 0.36 μM.


UBCS039 is an synthetic SIRT6 activator, with EC50 of 38 μM.

Nicotinamide Riboside Chloride

Nicotinamide Riboside Chloride is a pyridine-nucleoside form of vitamin B3 that functions as a precursor to nicotinamide adenine dinucleotide or NAD+.


SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.


SRT2104 is a selective brain-permeable activator of SIRT1.

Abmole Inhibitor Catalog 2017

Keywords: SRT1720 Hydrochloride, SRT-1720 Hydrochloride supplier, Sirtuin, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.