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Cat. No. M2267
Resveratrol Structure


Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
200mg USD 60 In stock
500mg USD 120 In stock
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Quality Control
Biological Activity

Resveratrol is a selective human cytochrome P450 1A1 inhibitor. Resveratrol slightly inhibited ethoxyresorufin O-deethylation (EROD) activity in human liver microsomes with an IC50 of 1.1 mM.

Cell Experiment
Cell lines CNE-1 and CNE-2Z cells
Preparation method Cell proliferation assay
The effect of resveratrol on the cell growth of CNE-1 and CNE-2Z cells was examined using the MTT assay. Cancer cells were plated in 96-well plates at 104 cells/well. Following pretreatment with different concentrations of resveratrol for 24 or 48 h, viable cells were determined using the MTT Assay kit (Chemicon, Temecula, CA, USA) according to the manufacturer’s protocol. At indicated time-points, 20 μl of MTT solution (5 mg/ml in PBS) were added into each well and incubated for 4 h. Then, 100 μl of DMSO was added to dissolve the crystals. The plate was then left to stand for 10 min at room temperature and the corresponding absorbance was measured at 490 nm. Each experiment was performed in triplicate.
Concentrations 0, 10, 25, 50 and 100 μM
Incubation time 24 or 48 h
Animal Experiment
Animal models female nude mice bearing CNE-2Z tumour xenograft model
Formulation 10% DMSO in PBS
Dosages 20 mg/kg once a day for 3 weeks
Administration i.p.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 228.24
Formula C14H12O3
CAS Number 501-36-0
Purity 99.94%
Solubility DMSO 40 mg/mL
Storage at -20°C

Resveratrol inhibits human nasopharyngeal carcinoma cell growth via blocking pAkt/p70S6K signaling pathways.
Zhang M, et al. Int J Mol Med. 2013 Mar;31(3):621-7. PMID: 23314035.

Resveratrol suppresses growth of human ovarian cancer cells in culture and in a murine xenograft model: eukaryotic elongation factor 1A2 as a potential target
Mee-Hyun Lee, et al. Cancer Res. 2009 Sep 15;69(18):7449-58. PMID: 19738051.

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Keywords: Resveratrol, trans-Resveratrol supplier, Sirtuin, inhibitors

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