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Resveratrol

Cat. No. M2267
Resveratrol Structure
Synonym:

trans-Resveratrol; SRT501

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
100mg USD 30  USD30 In stock
200mg USD 42  USD42 In stock
500mg USD 88  USD88 In stock
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Quality Control & Documentation
Biological Activity

Resveratrol is a selective human cytochrome P450 1A1 inhibitor. Resveratrol slightly inhibited ethoxyresorufin O-deethylation (EROD) activity in human liver microsomes with an IC50 of 1.1 mM. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator. Resveratrol is a potent pregnane X receptor (PXR) inhibitor. Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model. Resveratrol increases production of NO in endothelial cells.

Product Citations
Protocol (for reference only)
Cell Experiment
Cell lines CNE-1 and CNE-2Z cells
Preparation method Cell proliferation assay
The effect of resveratrol on the cell growth of CNE-1 and CNE-2Z cells was examined using the MTT assay. Cancer cells were plated in 96-well plates at 104 cells/well. Following pretreatment with different concentrations of resveratrol for 24 or 48 h, viable cells were determined using the MTT Assay kit (Chemicon, Temecula, CA, USA) according to the manufacturer’s protocol. At indicated time-points, 20 μl of MTT solution (5 mg/ml in PBS) were added into each well and incubated for 4 h. Then, 100 μl of DMSO was added to dissolve the crystals. The plate was then left to stand for 10 min at room temperature and the corresponding absorbance was measured at 490 nm. Each experiment was performed in triplicate.
Concentrations 0, 10, 25, 50 and 100 μM
Incubation time 24 or 48 h
Animal Experiment
Animal models female nude mice bearing CNE-2Z tumour xenograft model
Formulation 10% DMSO in PBS
Dosages 20 mg/kg once a day for 3 weeks
Administration i.p.
Chemical Information
Molecular Weight 228.24
Formula C14H12O3
CAS Number 501-36-0
Solubility (25°C) DMSO 46 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Zhang M, et al. Int J Mol Med. Resveratrol inhibits human nasopharyngeal carcinoma cell growth via blocking pAkt/p70S6K signaling pathways.

[2] Mee-Hyun Lee, et al. Cancer Res. Resveratrol suppresses growth of human ovarian cancer cells in culture and in a murine xenograft model: eukaryotic elongation factor 1A2 as a potential target

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Keywords: Resveratrol, trans-Resveratrol; SRT501 supplier, Sirtuin, inhibitors, activators


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