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Ganoderic-acid-D

Cat. No. M4306

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Ganoderic-acid-D Structure
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10mg USD 400  USD400 In stock
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Quality Control & Documentation
Biological Activity

Ganoderic acid D is a highly oxidized tetracyclic triterpenoid that is the main active ingredient in Ganoderma lucidum. Ganoderic acid D upregulates protein expression for SIRT3 and induces deacetylated cyclophilic protein D (CypD) through SIRT3. Ganoderic acid D inhibits energy reprogramming in colon cancer cells, including glucose uptake, lactate production, pyruvate, and acetyl-Coenzyme production in colon cancer cells.

Chemical Information
Molecular Weight 514.65
Formula C30H42O7
CAS Number 108340-60-9
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Yan Xu, et al. Ganoderic Acid D Protects Human Amniotic Mesenchymal Stem Cells against Oxidative Stress-Induced Senescence through the PERK/NRF2 Signaling Pathway

[2] Chang-Sheng Shao, et al. Ganoderic acid D induces synergistic autophagic cell death except for apoptosis in ESCC cells

[3] Zhendong Liu, et al. Effect of ganoderic acid D on colon cancer Warburg effect: Role of SIRT3/cyclophilin D

[4] Chun-Ru Cheng, et al. Pharmacokinetics of ganoderic acid D and its main metabolite by liquid chromatography-tandem mass spectrometry

[5] Chunru Cheng, et al. Identification of metabolites of ganoderic acid D by ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry

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Keywords: Ganoderic-acid-D supplier, Sirtuin, inhibitors, activators

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