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NRD167

Cat. No. M20828
NRD167 Structure
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Biological Activity

NRD167 is a potent and selective SIRT5 inhibitor.

Chemical Information
Molecular Weight 666.83
Formula C34H46N6O6S
CAS Number 2166487-23-4
Solubility (25°C) DMSO 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Meng Li, et al. Blood Cancer Discov. Non-oncogene Addiction to SIRT5 in Acute Myeloid Leukemia

[2] Dongqing Yan, et al. Blood Cancer Discov. SIRT5 IS A DRUGGABLE METABOLIC VULNERABILITY IN ACUTE MYELOID LEUKEMIA

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Keywords: NRD167 supplier, Sirtuin, inhibitors, activators

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