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Sirtuin Sirtuin

Cat.No.  Name Information
M1708 Selisistat (EX 527) Selisistat (EX 527) is a potent and selective SIRT1 class III histone deacetylase enzyme inhibitor with an IC50 of 98 nM.
M4896 Nicotinamide Nicotinamide is an active component of coenzymes NAD and NADP, and also act as an inhibitor of sirtuins. Nicotinamide plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions.
M1824 SRT1720 Hydrochloride SRT1720 Hydrochloride is a selective small molecule activator of SIRT1 that is 1,000-fold more potent than resveratrol (EC1.5 = 0.16 versus 46.2 µM, respectively). SRT1720 increased the activity of SIRT1 and AMPKα phosphorylation at Ser485 via the cAMP-protein kinase A (PKA) pathway.
M3010 Sirtinol Sirtinol is a specific SIRT1 and SIRT2 inhibitor with IC50 of 131 μM and 38 μM, respectively.
M2267 Resveratrol Resveratrol is a phytoestrogen with antitumor, antioxidant, antiplatelet, anti-inflammatory and antifungal effects.
M11030 SRT 1720 SRT 1720 is a potent activator of the human SIRT1, EC1.5 The value is 0.16 μM and simultaneously inhibits SIRT2 and SIRT3, EC1.5 The values are 37 μM and > 300 μM, respectively.
M5265 Thiomyristoyl Thiomyristoyl is a potent and specific SIRT2 inhibitor with an IC50 of 28 nM. It inhibits SIRT1 with an IC50 value of 98 μM and does not inhibit SIRT3 even at 200 μM.
M4678 Fisetin Fisetin (Fustel) is a potent sirtuin activating compound (STAC) and an agent that modulates sirtuins.
M6254 OSS_128167 OSS_128167 is a specific SIRT6 inhibitor with IC50 values of 89, 1578 and 751 μM for SIRT6, SIRT1 and SIRT2, respectively.
M9148 SRT2104 SRT2104 is a first-in-class, selective, blood-brain barrier-crossing SIRT1 activator for use in studies related to diabetes and Huntington's disease.
M8978 3-TYP 3-TYP is a selective SIRT3 inhibitor, more potent over SIRT1 and SIRT2, with IC50 values of 88 nM, 92 nM, 16 nM for SITR1, SIRT2, SIRT3, respectively.
M8500 AK-1 AK-1 is a cell permeable, potent and specific SIRT2 inhibitor that induced proteasomal degradation of the Snail transcription factor.
M8488 Ophiopogonin D' Ophiopogonin D', isolated from the tuber of Ophiopogon japonicus, is a rare naturally occurring C29 steroid glycoside. Ophiopogonin D' has cytotoxic activity against two human tumor cell lines mG-63 and SNU387. Ophiopogonin D' can induce necrotic apoptosis of prostate cancer LNCaP cells by activating RIPK1. IC50 were 3.09 μM and 3.63 μM, respectively. SIRT1 is activated in a dose-dependent manner by Ophiopogonin D'.
M8244 AK-7 AK-7 is a brain penetrant selective SIRT2 inhibitor, with an IC50 of 15.5 μM.
M7681 Cambinol Cambinol is an inhibitor of SIRT1 and SIRT2 with IC50 values of 56 μM and 59 μM, respectively. Cambinol also inhibited exosome release.
M7500 YK 3-237 YK 3-237 is a boronic acid chalcone analog of combretastatin a4 (CA-4) and a SIRT1 activator that targets mutant p53. YK 3-237 can reduce the acetylation of mutant p53 protein by activating the SIRT1 enzyme, resulting in a significant decrease in the level of mutant p53 protein. YK-3-237 showed antiproliferative activity against tumor cells containing mutant p53 protein.
M6414 AGK 2 AGK 2 is a selective SIRT2 inhibitor.
M6254 OSS_128167 OSS_128167 is a specific SIRT6 inhibitor with IC50 values of 89, 1578 and 751 μM for SIRT6, SIRT1 and SIRT2, respectively.
M6241 Tenovin 6 Hydrochloride Tenovin-6 Hydrochloride is a water soluble inhibitor of SIRT1 and SIRT2, slightly inhibits HDAC8, and is also a potent activator of p53, with IC50s of 21 μM, 10 μM, 67 μM for SirT1, SirT2, and SirT3, respectively.
M5262 Salermide Salermide is a reverse amide with a strong in vitro inhibitory effect on Sirt1 and Sirt2. Compared with Sirt1, Salermide is even more efficient at inhibiting Sirt2.
M4674 Agrimol-B Agrimol B is a polyphenol derivative isolated from Sepulchrum, which can inhibit fat formation, induce translocation and expression of SIRT1, and reduce the expression of PPARγ.
M4507 Scopolin Scopolin is a coumarin isolated from the roots of Arabidopsis. Scopolin mitigated hepatic steatosis by activating sirT1-mediated signaling cascades.
M4306 Ganoderic-acid-D Ganoderic acid D is a highly oxidized tetracyclic triterpenoid that is the main active ingredient in Ganoderma lucidum. Ganoderic acid D upregulates protein expression for SIRT3 and induces deacetylated cyclophilic protein D (CypD) through SIRT3. Ganoderic acid D inhibits energy reprogramming in colon cancer cells, including glucose uptake, lactate production, pyruvate, and acetyl-Coenzyme production in colon cancer cells.
M2429 Balsalazide disodium Balsalazide is an anti-inflammatory compound used to study inflammatory bowel disease and ulcerative colitis.
M45096 ADTL-SA1215 ADTL-SA1215 is a first-in-class, specific small molecule activator of SIRT3 that modulates autophagy in triple-negative breast cancer.
M41729 SIRT2/6-IN-1 SIRT2/6-IN-1 is a SIRT6/SIRT2 inhibitor, with IC50s of 106 μM and 114 μM.
M41606 SIRT6-IN-2 SIRT6-IN-2 is a selective SIRT6 inhibitor (IC50: 34 μM).
M41605 SIRT6-IN-3 SIRT6-IN-3 is a selective inhibitor of SIRT6 (IC50=7.49 μM).
M41604 Z26395438 Z26395438 is a potent Sirtuin-1 inhibitor, with an IC50 value of 1.6 μM.




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