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SRT2183

Cat. No. M10109
SRT2183 Structure
Synonym:

SRT-2183

Size Price Availability Quantity
5mg USD 130 In stock
10mg USD 190 In stock
25mg USD 400 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

SRT2183 is a selective activator of Sirtuin-1 (SIRT1) with EC1.5 value of 0.36 μM. SRT2183 induces growth arrest and apoptosis, concomitant with deacetylation of STAT3 and NF-κB, and reduction of c-Myc protein levels. SRT2183 leads to increased mRNA levels of pro-apoptosis and DNA-damage-response genes, accompanied by accumulation of phospho-H2A.X levels. SRT2183 reduces the DNA-binding activity of both NF-κB and STAT3 to the promoter of GADD45G, which is one of the most upregulated genes following SRT2183 treatment.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 468.57
Formula C27H24N4O2S
CAS Number 1001908-89-9
Purity >99%
Solubility DMSO ≥ 150 mg/mL
Storage at -20°C
References

SIRT1 activation enhances HDAC inhibition-mediated upregulation of GADD45G by repressing the binding of NF-κB/STAT3 complex to its promoter in malignant lymphoid cells
A Scuto, et al. Cell Death Dis. 2013 May 16;4(5):e635. PMID: 23681230.

Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
Jill C Milne, et al. Nature. 2007 Nov 29;450(7170):712-6. PMID: 18046409.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: SRT2183, SRT-2183 supplier, Sirtuin, inhibitors

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