Free shipping on all orders over $ 500

SRT2104

Cat. No. M9148
SRT2104 Structure
Synonym:

GSK2245840

Size Price Availability Quantity
5mg USD 120 In stock
10mg USD 190 In stock
50mg USD 550 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

SRT2104 is a selective brain-permeable activator of SIRT1. SRT2104 (3 μM) reduces p65/RelA acetylation levels in C2C12 cells.

In vivo, SRT2104 (100 mg/kg, p.o.) improves whole-body physiology and extends lifespan in mice fed a standard diet. SRT2104 increases mitochondrial content and suppresses the inflammatory response in SD-fed mice. In Male N171-82Q HD mice, SRT2104 (diet containing 0.5% SRT2104) effectively penetrates the blood-brain barrier, attenuates brain atrophy, improves motor function, and extends survival.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 516.64
Formula C26H24N6O2S2
CAS Number 1093403-33-8
Purity >98%
Solubility DMSO: 8 mg/mL (Need ultrasonic and warming)
Storage at -20°C
Related Sirtuin Products
SRT2183

SRT2183 is a selective activator of Sirtuin-1 (SIRT1) with EC1.5 value of 0.36 μM.

UBCS039

UBCS039 is an synthetic SIRT6 activator, with EC50 of 38 μM.

Nicotinamide Riboside Chloride

Nicotinamide Riboside Chloride is a pyridine-nucleoside form of vitamin B3 that functions as a precursor to nicotinamide adenine dinucleotide or NAD+.

SirReal2

SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.

3-TYP

3-TYP is a selective SIRT3 inhibitor, more potent over SIRT1 and SIRT2, with IC50 values of 88 nM, 92 nM, 16 nM for SITR1, SIRT2, SIRT3, respectively.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: SRT2104, GSK2245840 supplier, Sirtuin, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.