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AK-7 is a brain penetrant selective SIRT2 inhibitor, with an IC50 of 15.5 μM. AK-7 (10 μM) reduces cholesterol levels in naive N2a neuroblastoma cells and hippocampal slice cultures from wild-type mice. AK-7 (1 μM) shows neuroprotective effect of AK-7 in striatal Huntington’s disease (HD) neurons. AK-7 (12.5 μM) decreases ratio of DA neurons in primary midbrain cultures.
| Molecular Weight | 437.35 |
| Formula | C19H21BrN2O3S |
| CAS Number | 420831-40-9 |
| Form | Solid |
| Solubility (25°C) | DMSO 45 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Sirtuin Products |
|---|
| SIRT1-IN-1
SIRT1-IN-1 is a selective SIRT1 inhibitor with an IC50 of 0.205 μM. |
| Sirtuin-1 inhibitor 1
Sirtuin-1 inhibitor 1 is an inhibitor of Sirtuin-1 that plays important roles in obesity-induced diabetes and aging-related diseases. |
| ADTL-SA1215
ADTL-SA1215 is a first-in-class, specific small molecule activator of SIRT3 that modulates autophagy in triple-negative breast cancer. |
| SIRT2/6-IN-1
SIRT2/6-IN-1 is a SIRT6/SIRT2 inhibitor, with IC50s of 106 μM and 114 μM. |
| SIRT6-IN-2
SIRT6-IN-2 is a selective SIRT6 inhibitor (IC50: 34 μM). |
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