| Cat.No. | Name | Information |
|---|---|---|
| M1708 | Selisistat (EX 527) | Selisistat (EX 527) is a potent and selective SIRT1 class III histone deacetylase enzyme inhibitor with an IC50 of 98 nM. |
| M4896 | Nicotinamide | Nicotinamide is an active component of coenzymes NAD and NADP, and also act as an inhibitor of sirtuins. Nicotinamide plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. |
| M1824 | SRT1720 Hydrochloride | SRT1720 Hydrochloride is a selective small molecule activator of SIRT1 that is 1,000-fold more potent than resveratrol (EC1.5 = 0.16 versus 46.2 µM, respectively). SRT1720 increased the activity of SIRT1 and AMPKα phosphorylation at Ser485 via the cAMP-protein kinase A (PKA) pathway. |
| M3010 | Sirtinol | Sirtinol is a specific SIRT1 and SIRT2 inhibitor with IC50 of 131 μM and 38 μM, respectively. |
| M2267 | Resveratrol | Resveratrol is a phytoestrogen with antitumor, antioxidant, antiplatelet, anti-inflammatory and antifungal effects. |
| M11030 | SRT 1720 | SRT 1720 is a potent activator of the human SIRT1, EC1.5 The value is 0.16 μM and simultaneously inhibits SIRT2 and SIRT3, EC1.5 The values are 37 μM and > 300 μM, respectively. |
| M5265 | Thiomyristoyl | Thiomyristoyl is a potent and specific SIRT2 inhibitor with an IC50 of 28 nM. It inhibits SIRT1 with an IC50 value of 98 μM and does not inhibit SIRT3 even at 200 μM. |
| M4678 | Fisetin | Fisetin (Fustel) is a potent sirtuin activating compound (STAC) and an agent that modulates sirtuins. |
| M6254 | OSS_128167 | OSS_128167 is a specific SIRT6 inhibitor with IC50 values of 89, 1578 and 751 μM for SIRT6, SIRT1 and SIRT2, respectively. |
| M41603 | CrBKA | CrBKA is a fluorogenic small-molecule substrate of SIRT6 with weak activity. |
| M41602 | SPC-180002 | SPC-180002 is a SIRT1/3 dual inhibitor, with IC50 values of 1.13 and 5.41 μM, respectively. |
| M41601 | SIRT5 inhibitor 6 | SIRT5 Inhibitor 6 is a potent, substrate-competitive and selective SIRT5 inhibitor with an IC50 of 3.0 μM. |
| M41600 | Sirt1/2-IN-3 | Sirt1/2-IN-3 is a dual inhibitor of SIRT1/2 with IC50s of 1.4 μM (SIRT1) and 2.0 μM (SIRT2), respsectivley. |
| M41599 | Sirt1/2-IN-2 | Sirt1/2-IN-2 is a dual inhibitor of SIRT1/2 with IC50s of 1.8 μM (SIRT1) and 2.4 μM (SIRT2), respsectivley. |
| M41598 | Sirt1/2-IN-4 | Sirt1/2-IN-4 is a triple inhibitor of SIRT1/2/3 with IC50s of 1.2 μM (SIRT1), 1.9 μM (SIRT2), and 18.6 μM (SIRT3), respsectivley. |
| M38946 | Cannabisin F | Cannabisin F is a SIRT1 modulator. Cannabisin F, as a hempseed lignanamide, can be used for the research of anti-inflammatory and anti-oxidative. Cannabisin F may be a potential agent of neurodegenerative diseases as modulators of SIRT1/NF-κB and Nrf2. |
| M38945 | Guttiferone G | Guttiferone G inhibits recombinant human SIRT1 and SIRT2 (IC50: 9 and 22 μM, respectively). Guttiferone G is weakly cytotoxic in A2780 human ovarian cell line (IC50: 8.0 μg/mL). Guttiferone G can be isolated from Garcinia macrophylla. |
| M38944 | 3β,6α,12β-Dammar-E-20(22)-ene-3,6,12,25-tetraol | 3β,6α,12β-Dammar-E-20(22)-ene-3,6,12,25-tetraol, a SIRT1 activator, exhibits significant stimulation of SIRT1 activity. Anti-tumor activity. |
| M30683 | (R)-Selisistat | (R)-Selisistat ((R)-EX-527) is a R-enantiomer of Selisistat. Selisistat (EX-527) is a potent and selective SIRT1 inhibitor with IC50 of 98 nM. |
| M30682 | (S)-Selisistat | (S)-Selisistat ((S)-EX-527) is a potent and selective SIRT1 inhibitor, with an IC50 of 98 nM. |
| M29225 | PROTAC Sirt2 Degrader-1 | PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a bona fide Cereblon ligand for E3 ubiquitin ligase. PROTAC Sirt2 Degrader-1 shows an IC50 of 0.25 μM for Sirt2, with no effect on Sirt1/Sirt3 (IC50s>100 μM). |
| M27933 | SRTCX1003 | SRTCX1003 is an orally active SIRT1 activator. SRTCX1003 suppresses inflammatory responses. |
| M27932 | SRTCX1002 | SRTCX1002 is a potent activator of SIRT1 (STAC), suppresses inflammatory responses through promotion of p65 deacetylation and inhibition of NF-κB Activity. SRTCX1002 suppresses stimuli-induced NF-κB transcriptional activation and LPS-induced TNFα secretion with IC50s of 0.71 and 7.58 µM, respectively. |
| M27669 | E1231 | E1231 is an orally active activator of Sirtuin 1 (SIRT1) (EC50=0.83 μM), to modulate cholesterol and lipid metabolism. E1231 interactes with SIRT1 (KD=9.61 μM) and deacetylated liver X receptor-alpha (LXRα), and increases ATP-binding cassette transporter A1 (ABCA1) expression. E1231 also reduces atherosclerotic plaque development in ApoE-/- mice model. E1231 can be used for research in cholesterol and lipid disorder-related diseases. |
| M20666 | Gardenia yellow | Gardenia yellow is an active member of crocin, increases mRNA expression of SIRT3, and acts as an orally active antidepressant agent. |
| M20624 | SRT3025 HCl | SRT3025 is an orally available small molecule activator of the SIRT1 enzyme. |
| M20212 | WAY-616312 | WAY-616312 is a sirtuin modulator. |
| M20020 | CL-59089 | CL-59089 is a sirtuin modulator. |
| M13736 | SIRT-IN-3 | SIRT-IN-3 is a potent SIRT inhibitor, with an IC50 of 17 μM for SIRT1. SIRT-IN-3 shows about 4-fold and 14-fold selectivity for SIRT1 over SIRT2 and SIRT3, respectively (IC50 of 74 μM and 235 μM for SIRT2 and SIRT3, respectively). |
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