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SIRT5 inhibitor 6

Cat. No. M41601
SIRT5 inhibitor 6 Structure
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Biological Activity

SIRT5 Inhibitor 6 is a potent, substrate-competitive and selective SIRT5 inhibitor with an IC50 of 3.0 μM.

Chemical Information
Molecular Weight 460.55
Formula C21H28N6O4S
CAS Number 2834736-82-0
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Lijiao Wang et al. Bioorg Med Chem. Design, synthesis and biological evaluation of 2,4,6- trisubstituted triazine derivatives as new nonpeptide small-molecule SIRT5 inhibitors

[2] Emanuele Fabbrizi et al. Cells. Emerging Roles of SIRT5 in Metabolism, Cancer, and SARS-CoV-2 Infection

[3] Vishal Kumar et al. Curr Neuropharmacol. Understanding the Role of Histone Deacetylase and their Inhibitors in Neurodegenerative Disorders: Current Targets and Future Perspective

[4] Jiajia Liu et al. Molecules. A Selective Cyclic Peptidic Human SIRT5 Inhibitor

[5] Lucia Polletta et al. Autophagy. SIRT5 regulation of ammonia-induced autophagy and mitophagy

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