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(S)-Selisistat ((S)-EX-527) is a potent and selective SIRT1 inhibitor, with an IC50 of 98 nM.
| Molecular Weight | 248.71 |
| Formula | C13H13ClN2O |
| CAS Number | 848193-68-0 |
| Form | Solid |
| Solubility (25°C) | DMSO ≥ 100 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Xinfa Bai, et al. Mini Rev Med Chem. Small Molecules as SIRT Modulators
| Related Sirtuin Products |
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Sirtuin-1 inhibitor 1 is an inhibitor of Sirtuin-1 that plays important roles in obesity-induced diabetes and aging-related diseases. |
| ADTL-SA1215
ADTL-SA1215 is a first-in-class, specific small molecule activator of SIRT3 that modulates autophagy in triple-negative breast cancer. |
| SIRT2/6-IN-1
SIRT2/6-IN-1 is a SIRT6/SIRT2 inhibitor, with IC50s of 106 μM and 114 μM. |
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SIRT6-IN-2 is a selective SIRT6 inhibitor (IC50: 34 μM). |
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