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Guttiferone G

Cat. No. M38945

All AbMole products are for research use only, cannot be used for human consumption.

Guttiferone G Structure

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Biological Activity

Guttiferone G inhibits recombinant human SIRT1 and SIRT2 (IC50: 9 and 22 μM, respectively). Guttiferone G is weakly cytotoxic in A2780 human ovarian cell line (IC50: 8.0 μg/mL). Guttiferone G can be isolated from Garcinia macrophylla.

Chemical Information
Molecular Weight 670.92
Formula C43H58O6
CAS Number 666174-75-0
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Aimé Gabriel Fankam et al. Biomed Res Int. Guttiferone BL from the Fruits of Allanblackia gabonensis Induces Mitochondrial-Dependent Apoptosis in PA-1 Ovarian Cancer Cells

[2] Nicholas A McGrath et al. Chem Commun (Camb). An efficient oxidative dearomatization-radical cyclization approach to symmetrically substituted bicyclic guttiferone natural products

[3] Claudia Gey et al. Angew Chem Int Ed Engl. Phloroglucinol derivatives guttiferone G, aristoforin, and hyperforin: inhibitors of human sirtuins SIRT1 and SIRT2

[4] Russell B Williams et al. Planta Med. A novel cytotoxic guttiferone analogue from Garcinia macrophylla from the Suriname rainforest

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Keywords: Guttiferone G supplier, Sirtuin, inhibitors, activators

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