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OSS_128167

Cat. No. M6254

All AbMole products are for research use only, cannot be used for human consumption.

OSS_128167 Structure
Synonym:

SIRT6-IN-1; OSS-128167

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
5mg USD 95  USD95 In stock
10mg USD 133  USD133 In stock
25mg USD 255  USD255 In stock
50mg USD 430  USD430 In stock
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Quality Control & Documentation
Biological Activity

OSS-128167 proves to be a selective compounds toward SIRT6, its IC50 values toward SIRT1 and SIRT2 being approximately 20 times higher. It is cell permeable and active in cultured cells. 

OSS-128167 increases H3K9 acetylation and GLUT-1 expression. OSS_128167 effectively blunts phorbol myristate acetate (PMA)-induced TNF-α secretion in cultured BxPC-3 cells. OSS_128167 increases glucose uptake in cells. OSS_128167 (200 μM) induces chemosensitization in primary multiple myeloma (MM) cells (NCI-H929), as well as in melphalan-resistant (LR-5) and doxorubicin-resistant (Dox40) MM cell lines. 

In vivo, OSS_128167 (50 mg/kg; intraperitoneal injection; every 4 days; for 12 days; male HBV transgenic mice) treatment markedly suppresses the level of HBV DNA and 3.5-Kb RNA in HBV transgenic mice.

Product Citations
Protocol (for reference only)
Cell Experiment
Cell lines BxPC3 cells
Preparation method 4 × 10^5 BxPC3 cells are plated in six-well plates and allowed to adhere for 24 h. There after, cells are stimulated with 100 μM OSS-128167 or the respective amounts of vehicle DMSO for the indicated time amounts. Finally, cells are used for protein lysate generation, and total H3 and acetylated H3K9 levels are detected by immunoblotting.
Concentrations 100 μM
Incubation time 0, 2, 6, 18, 24 h
Animal Experiment
Animal models
Formulation
Dosages
Administration
Chemical Information
Molecular Weight 366.32
Formula C19H14N2O6
CAS Number 887686-02-4
Solubility (25°C) DMSO 80 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Cea M, et al. Blood. Evidence for a role of the histone deacetylase SIRT6 in DNA damage response of multiple myeloma cells.

[2] Parenti MD, et al. J Med Chem. Discovery of novel and selective SIRT6 inhibitors.

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Keywords: OSS_128167, SIRT6-IN-1; OSS-128167 supplier, Sirtuin, inhibitors, activators

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