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Nicotinamide riboside

Cat. No. M11201
Nicotinamide riboside  Structure
Synonym:

BETA-nicotinamide ribose;Beta-Nicotinamide Riboside

Size Price Availability Quantity
5mg USD 35  USD35 In stock
10mg USD 50  USD50 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Nicotinamide riboside is a precursor to nadir with oral activity that increases NAD levels and activates SIRT1 and SIRT3. Nicotinamide riboside is a source of vitamin B3 (niacin) that enhances oxidative metabolism and prevents metabolic abnormalities induced by a high-fat diet. Nicotinamide riboside can reduce cognitive degradation in transgenic mouse models of Alzheimer's disease.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 255.25
Formula C11H15N2O5+
CAS Number 1341-23-7
Purity >99%
Solubility DMSO: 10 mM
Storage at -20°C
References

[1] Mario Mehmel, et al. Nutrients. Nicotinamide Riboside-The Current State of Research and Therapeutic Uses

[2] Yasir S Elhassan, et al. Cell Rep. Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD + Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures

[3] Christopher R Martens, et al. Nat Commun. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD + in healthy middle-aged and older adults

[4] Nicolas Diguet, et al. Circulation. Nicotinamide Riboside Preserves Cardiac Function in a Mouse Model of Dilated Cardiomyopathy

[5] Katrina L Bogan, et al. Annu Rev Nutr. Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition

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Keywords: Nicotinamide riboside , BETA-nicotinamide ribose;Beta-Nicotinamide Riboside supplier, Sirtuin, inhibitors

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