Free shipping on all orders over $ 500

CL-59089

Cat. No. M20020
CL-59089 Structure
Size Price Availability
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

CL-59089 is a sirtuin modulator.

Chemical Information
Molecular Weight 199.27
Formula C8H13N3OS
CAS Number 3008-61-5
Solubility (25°C) DMSO 10mM
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Related Sirtuin Products
ADTL-SA1215

ADTL-SA1215 is a first-in-class, specific small molecule activator of SIRT3 that modulates autophagy in triple-negative breast cancer.

SIRT2/6-IN-1

SIRT2/6-IN-1 is a SIRT6/SIRT2 inhibitor, with IC50s of 106 μM and 114 μM.

SIRT6-IN-2

SIRT6-IN-2 is a selective SIRT6 inhibitor (IC50: 34 μM).

SIRT6-IN-3

SIRT6-IN-3 is a selective inhibitor of SIRT6 (IC50=7.49 μM).

Z26395438

Z26395438 is a potent Sirtuin-1 inhibitor, with an IC50 value of 1.6 μM.

  Catalog
Abmole Inhibitor Catalog




Keywords: CL-59089 supplier, Sirtuin, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.