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Sodium iodate

Cat. No. M21440
Sodium iodate Structure
Size Price Availability Quantity
1g USD 40  USD40 In stock
5g USD 60  USD60 In stock
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Quality Control & Documentation
Biological Activity

Sodium iodate is an inorganic compound with the chemical formula NaIO3 and can be used as an oxidant.

Product Citations
Chemical Information
Molecular Weight 197.89
Formula INaO3
CAS Number 7681-55-2
Solubility (25°C) Soluble in Water
Storage RT, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Chengda Ren, et al. Oxid Med Cell Longev. Nicotinamide Mononucleotide Ameliorates Cellular Senescence and Inflammation Caused by Sodium Iodate in RPE

[2] Jong-Jer Lee, et al. Oxid Med Cell Longev. 5-Lipoxygenase Inhibition Protects Retinal Pigment Epithelium from Sodium Iodate-Induced Ferroptosis and Prevents Retinal Degeneration

[3] Anne Enzbrenner, et al. Int J Mol Sci. Sodium Iodate-Induced Degeneration Results in Local Complement Changes and Inflammatory Processes in Murine Retina

[4] Binghua Liu, et al. Cell Death Dis. Sodium iodate induces ferroptosis in human retinal pigment epithelium ARPE-19 cells

[5] Chi-Ming Chan, et al. J Biomed Sci. Reactive oxygen species-dependent mitochondrial dynamics and autophagy confer protective effects in retinal pigment epithelial cells against sodium iodate-induced cell death

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