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Acrylamide

Cat. No. M11469
Acrylamide Structure
Size Price Availability Quantity
100g USD 60  USD60 In stock
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Quality Control & Documentation
Biological Activity

Acrylamide is a neurotoxic monomer with a wide range of industrial uses. It is a precursor compound of polyacrylamide.

Chemical Information
Molecular Weight 71.08
Formula C3H5NO
CAS Number 79-06-1
Solubility (25°C) DMSO ≥ 10 mg/mL
Storage 2-8°C
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Agnieszka Koszucka, et al. Crit Rev Food Sci Nutr. Acrylamide in human diet, its metabolism, toxicity, inactivation and the associated European Union legal regulations in food industry

[2] Shinomol George Kunnel, et al. Cent Nerv Syst Agents Med Chem. Acrylamide Induced Toxicity and the Propensity of Phytochemicals in Amelioration: A Review

[3] Viviane Matoso, et al. Food Chem. Acrylamide: A review about its toxic effects in the light of Developmental Origin of Health and Disease (DOHaD) concept

[4] Claudio Pelucchi, et al. Int J Cancer. Dietary acrylamide and cancer risk: an updated meta-analysis

[5] No authors listed. IARC Monogr Eval Carcinog Risks Hum. Acrylamide

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